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Rosuvastatin Anhydro Lactone is an intermediate compound in the synthesis of Rosuvastatin (R700500) derivatives, which are a class of statin drugs used for lowering cholesterol levels in the body.
Used in Pharmaceutical Industry:
Rosuvastatin Anhydro Lactone is used as a key intermediate in the production of Rosuvastatin derivatives for the treatment of hypercholesterolemia. It plays a crucial role in the synthesis process, enabling the development of effective cholesterol-lowering medications.

1246665-85-9

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1246665-85-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1246665-85-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,6,6,6 and 5 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1246665-85:
(9*1)+(8*2)+(7*4)+(6*6)+(5*6)+(4*6)+(3*5)+(2*8)+(1*5)=179
179 % 10 = 9
So 1246665-85-9 is a valid CAS Registry Number.

1246665-85-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name (S,E)-N-(4-(4-fluorophenyl)-6-isopropyl-5-(2-(6-oxo-3,6-dihydro-2H-pyran-2-yl)vinyl)pyrimidin-2-yl)-N-methylmethanesulfonamide

1.2 Other means of identification

Product number -
Other names Rosuvastatin Anhydro Lactone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1246665-85-9 SDS

1246665-85-9Upstream product

1246665-85-9Downstream Products

1246665-85-9Relevant academic research and scientific papers

Lactone pathway to statins utilizing the wittig reaction. the synthesis of rosuvastatin

Casar, Zdenko,Steinbuecher, Miha,Kosmrlj, Janez

scheme or table, p. 6681 - 6684 (2010/12/19)

The first entry to statins via lactonized side chain is reported, exemplified by the synthesis of rosuvastatin. The key step is Wittig coupling of (2S,4R)-4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2H-pyran-2-carbaldehyde and phosphonium salt of an appropriately functionalized pyrimidine heterocy'le. One-pot deprotection and hydrolysis of the resulting 4-O-TBS rosuvastatin lactone provided rosuvastatin in high yield.

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