124667-89-6Relevant academic research and scientific papers
Application of dibutyltin oxide method to regioselective acylation and alkylation of tylosin at C-4''.
Kiyoshima,Sakamoto,Ishikura,Fukagawa,Yoshioka,Naganawa,Sawa,Takeuchi
, p. 861 - 865 (1989)
4''-O-Acyl-, 4''-O-alkyl- and 4''-deoxy-tylosin derivatives were synthesized using 2'-O-acetyl-3'',4''-O-(dibutyl-stannio)tylosin as a synthetic intermediate. The in vitro biological evaluation showed that the new derivatives were active against macrolide-resistant clinical isolates of bacteria and mycoplasmas, and that they were resistant to hepatic esterase.
