Application of dibutyltin oxide method to regioselective acylation and alkylation of tylosin at C-4''.

DOI: 10.1248/cpb.37.861

Source and publish data:

Chemical and pharmaceutical bulletin p. 861 - 865 (1989)

Update date:2022-09-26

Topics:

Authors:

Kiyoshima

Sakamoto

Ishikura

Fukagawa

Yoshioka

Naganawa

Sawa Sawa

Takeuchi

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Article abstract of DOI:10.1248/cpb.37.861

4''-O-Acyl-, 4''-O-alkyl- and 4''-deoxy-tylosin derivatives were synthesized using 2'-O-acetyl-3'',4''-O-(dibutyl-stannio)tylosin as a synthetic intermediate. The in vitro biological evaluation showed that the new derivatives were active against macrolide-resistant clinical isolates of bacteria and mycoplasmas, and that they were resistant to hepatic esterase.

Full text of DOI:10.1248/cpb.37.861

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