Cas 1246744-78-4,C25H24N2O7

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Check Digit Verification of cas no

The CAS Registry Mumber 1246744-78-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,6,7,4 and 4 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1246744-78:
(9*1)+(8*2)+(7*4)+(6*6)+(5*7)+(4*4)+(3*4)+(2*7)+(1*8)=174
174 % 10 = 4
So 1246744-78-4 is a valid CAS Registry Number.

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1246744-78-4Relevant academic research and scientific papers

Inhibition of interleukin-1β converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketones

Galatsis, Paul,Caprathe, Bradley,Downing, Dennis,Gilmore, John,Harter, William,Hays, Sheryl,Kostlan, Catherine,Linn, Kristin,Lunney, Elizabeth,Para, Kim,Thomas, Anthony,Warmus, Joseph,Allen, Hamish,Brady, Kenneth,Talanian, Robert,Walker, Nigel

, p. 5089 - 5094 (2010)

A series of acyloxyalkyl and amidooxyalkyl ketones appended to a carbobenzyloxy aspartic acid core have been prepared. The most potent of these new inhibitors was 4i with a Ki of 0.5 μM. These two series provide an improved understanding of the binding requirements for the hydrophobic prime side of ICE.

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