1246748-08-2Relevant academic research and scientific papers
Synthesis of novel acyclic nucleoside analogues with anti-retroviral activity
Paju,Paeri,Selyutina,Zusinaite,Merits,Pehk,Siirde,Mueuerisepp,Kailas,Lopp
experimental part, p. 707 - 720 (2011/06/21)
A series of novel acyclic thymine nucleoside analogues were prepared by the Mitsunobu reaction from appropriately protected chiral triols. The enantiomeric triols were obtained from substituted-lactone acids, prepared by asymmetric oxidation of 3-substituted-1,2-cyclopentanediones. The cytotoxic activity of new analogues was evaluated on MCF-7 human breast cancer and HeLa cells, and antiviral activities on human immunodeficiency virus type 1 and hepatitis C virus models. The synthesized compounds revealed specific anti-retroviral activity and no cytotoxic side effects. Taylor and Francis Group, LLC.
