1246766-91-5

Upstream product

• 4509-90-4 5-bromovaleroyl chloride 
• 1246766-89-1 N-(5-amino-2-methylphenyl)-4-(3,4,5-trimethoxyphenyl)-2-pyrimidineamine 

Downstream Products

• 1246766-94-8 C₄₂H₅₂N₆O₉S₂ 
• 1246766-93-7 C₄₂H₅₁FN₆O₉S₂ 

Relevant academic research and scientific papers

Synthesis and biological evaluation of anilino substituted pyrimidine linked pyrrolobenzodiazepines as potential anticancer agents

A series of new anilino substituted pyrimidine linked pyrrolo[2,1-c][1,4] benzodiazepine (PBD) conjugates were prepared and evaluated for their anticancer activity. The effects of four promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These compounds showed the characteristic features of apoptosis like enhancement in the levels of p53, release of cytochrome c, and cleavage of PARP.