1246766-89-1

Upstream product

• 99-55-8 2-methyl-5-nitroaniline 
• 152460-08-7 1-(2-methyl-5-nitrophenyl)guanidine nitrate 
• 10078-54-3 3-(N,N-dimethylamino)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 1136-86-3 methyl (3,4,5-trimethoxyphenyl) ketone 
• 1246766-88-0 N-(5-nitro-2-methylphenyl)-4-(3,4,5-trimethoxyphenyl)-2-pyrimidineamine 

Downstream Products

• 1246766-91-5 C₂₅H₂₉BrN₄O₄ 
• 1349893-86-2 N-(4-methyl-3-(4-(3,4,5-trimethoxyphenyl)pyrimidin-2-ylamino)phenyl)biphenyl-4-sulfonamide 
• 1349893-88-4 3,4-dimethoxy-N-(4-methyl-3-(4-(3,4,5-trimethoxyphenyl)pyrimidin-2-ylamino)phenyl)benzenesulfonamide 
• 1349893-87-3 4-methoxy-N-(4-methyl-3-(4-(3,4,5-trimethoxyphenyl)pyrimidin-2-ylamino)phenyl)benzenesulfonamide 
• 1349893-89-5 N-(4-methyl-3-(4-(3,4,5-trimethoxyphenyl)pyrimidin-2-ylamino)phenyl)naphthalene-2-sulfonamide 

Relevant academic research and scientific papers

Synthesis and apoptosis inducing ability of new anilino substituted pyrimidine sulfonamides as potential anticancer agents

A series of anilino substituted pyrimidine sulfonamides were prepared and evaluated for their anticancer activity. These sulfonamides showed promising activity with IC50 values ranging from 5.6 to 12.3 μM. The detailed biological aspects of some of the promising compounds (3d, 3e and 3g) on the K562 cell line were studied. Interestingly, compounds induced G1 cell cycle arrest and down regulation of G1 phase cell cycle regulatory proteins such as cyclin D1, CDK4. These compounds also exhibited inhibition of NF-κB as well as its downstream target gene Akt1 and the phosphorylated form of AKt ser 474 proteins. One of the representative compound 3e could be considered as the potential lead for its development as a new anticancer agent.

Synthesis and biological evaluation of anilino substituted pyrimidine linked pyrrolobenzodiazepines as potential anticancer agents

A series of new anilino substituted pyrimidine linked pyrrolo[2,1-c][1,4] benzodiazepine (PBD) conjugates were prepared and evaluated for their anticancer activity. The effects of four promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These compounds showed the characteristic features of apoptosis like enhancement in the levels of p53, release of cytochrome c, and cleavage of PARP.