124679-92-1Relevant academic research and scientific papers
One-pot sequential N and C arylations: An efficient methodology for the synthesis of trans 4-N,N-diaryl aminostilbenes
Nandakumar, Mecheril V.,Verkade, John G.
, p. 3115 - 3118 (2005)
(Chemical Equation Presented) A double-amination/intermolecular-Heck- reaction sequence is used as a one-pot methodology for sequential C-N and C-C bond formations. 4-Aminostyrene was coupled with aryl bromides and aryl iodides using a [Pd2(dba)3]/proazaphosphatrane catalyst system (dba = dibenzylideneacetone; see scheme) to form irons 4-N,N-diaryl aminostilbene derivatives in high yields, which are comparable to those of previously reported multistep syntheses.
One pot sequential reactions and novel products produced thereby
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Page/Page column 10-12, (2010/11/24)
A method for producing sequenced reaction products comprising performing, in one pot, a first reaction at a lower temperature followed by a second reaction at a higher temperature in the presence of a catalyst system comprising a proazahosphatrane in combination with a palladium compound is provided. In one embodiment, the first reaction is a double amination reaction and the second reaction is an arylation. Use of one pot and a single catalyst system for each set of sequential reactions is efficient and economical. Novel N,N-diarylaminostyrenes and N,N-diarylaminostilbenes are produced according to the methods described herein.
Pd2dba3/P(i-BuNCH2CH2) 3N: A highly efficient catalyst for the one-pot synthesis of trans-4-N,N-diarylaminostilbenes and N,N-diarylaminostyrenes
Nandakumar, Mecheril V.,Verkade, John G.
, p. 9775 - 9782 (2007/10/03)
A Pd2dba3/P(i-BuNCH2CH2) 3N catalyzed one-pot synthesis of unsymmetrically substituted trans-4-N,N-diarylaminostilbenes and both symmetrically and unsymmetrically substituted N,N-diarylaminostyrene derivatives is reported. The procedure involves two or more palladium catalyzed sequential coupling reactions (an amination and an inter-molecular Heck reaction) in one-pot using the same catalyst system with two different aryl halides, including aryl chlorides and hetero aryl halides as the coupling partners.
