1246812-40-7

Basic information

• Product Name: Mono-POC Isopropyl Tenofovir (Mixture of DiastereoMers)
• Synonyms: (8R)-9-(6-Amino-9H-purin-9-yl)-8-methyl-5-(1-methylethoxy)-2,4,7-trioxa-5-phosphanonanoic acid 1-methylethyl ester 5-oxide;Tenofovir Disoproxil Related Compound G (15 mg) (O-(Isopropoxycarbonyloxymethyl)-O-isopropyl-{(R)-[1-(6-amino-9H-purin-9-yl)propan-2-yloxy]}methylphosphonate) fumarate);((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(isopropoxy)phosphoryl)oxy)methyl isopropyl carbonate;Mono-POC Isopropyl Tenofovir (Mixture of DiastereoMers);iPr-POC PMPA;Tenofovir Disoproxil Related CoMpound G;Tenofovir impurity K;Tenofovir isoproxil isoproxil
• CAS NO: 1246812-40-7
• Molecular Formula: C17H28N5O7P
• Molecular Weight: 445.407281
• Product Categories: Amines;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Phosphorylating and Phosphitylating Agents
• Mol File: 1246812-40-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 592.3±60.0 °C(Predicted)
• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20?C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 4.20±0.10(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: Mono-POC Isopropyl Tenofovir (Mixture of DiastereoMers)(CAS DataBase Reference)
• NIST Chemistry Reference: Mono-POC Isopropyl Tenofovir (Mixture of DiastereoMers)(1246812-40-7)
• EPA Substance Registry System: Mono-POC Isopropyl Tenofovir (Mixture of DiastereoMers)(1246812-40-7)

Safety Data

• Hazardous Substances Data: 1246812-40-7(Hazardous Substances Data)

Usage

Chemical Properties

Thick Yellow Oil

Upstream product

• 35180-01-9 chloromethyl isopropyl carbonate 
• 180587-75-1 (R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate 
• 14047-28-0 (R)-9-(2-hydroxypropyl)adenine 
• 66224-66-6 adenine 
• 75-26-3 isopropyl bromide 
• 211364-69-1 Tenofovir mono-POC 

Relevant articles and documents

Synthesis method of tenofovir disoproxil fumarate impurity

The invention relates to a synthesis method of a tenofovir disoproxil fumarate impurity. The tenofovir disoproxil fumarate impurity is (R)-[[2-(6-amino-9H-purine-9-radical)-1-methylethoxy]methyl]-(isopropoxy)-phosphoric acid isopropoxy carbonyl oxymethyl ester, and is prepared by using T-A:(R)-(1-(6-amino-9H-purine-9-radical)propyl-2-radical)oxygroup) methyl)phosphonic acid, N,N-diisopropylethylamine (DIPEA) and 1-(3-dimethyl amino propyl)-3-ethyl carbon diimine hydrochloride (EDC.HCL) as starting materials and two processes of esterification reaction and condensation reaction. According to the synthesis method, reaction raw materials are relatively readily available, the reaction process is easy to operate, requirements on reaction equipment are low, the reaction condition is relatively mild, the yield and purity are high, the cost is saved, and the synthesis method has great acceleration effect on more in-depth and extensive research of related drug use safety, reliability and stability of tenofovir disoproxil fumarate and quality control in the production process.