1246814-11-8

Basic information

• Product Name: 3,7,4'-tri-O-tert-butyldimethylsilylkaempferol
• Synonyms: 3,7,4'-tri-O-tert-butyldimethylsilylkaempferol
• CAS NO: 1246814-11-8
• Molecular Weight: 629.029
• Mol File: 1246814-11-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,7,4'-tri-O-tert-butyldimethylsilylkaempferol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,7,4'-tri-O-tert-butyldimethylsilylkaempferol(1246814-11-8)
• EPA Substance Registry System: 3,7,4'-tri-O-tert-butyldimethylsilylkaempferol(1246814-11-8)

Safety Data

• Hazardous Substances Data: 1246814-11-8(Hazardous Substances Data)

Upstream product

• 520-18-3 kaempferol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1246814-12-9 7,4'-di-O-tert-butyldimethylsilylkaempferol 

Relevant articles and documents

Highly efficient synthesis of flavonol 5-O-glycosides with glycosyl ortho-alkynylbenzoates as donors

With glycosyl ortho-alkynylbenzoates as donors, the highly efficient glycosylation of flavonoid 5-OH which are notorious for their low reactivity due to their involvement in the formation of strong intramolecular H-bonds was achieved under the catalysis of a Au(i) complex. Thus, a series of flavonoid 5-O-glycosides, including a kaempferol 5-O-disaccharide, were synthesized with good to excellent yields.

Synthesis of kaempferol 3- O -(3″,6″-Di- O - E - p -coumaroyl)-β- D -glucopyranoside, efficient glycosylation of flavonol 3-OH with glycosyl o -alkynylbenzoates as donors

Kaempferol 3-O-(3″,6″-di-O-E-p-coumaroyl)-β-d- glucopyranoside (1), an optimal metabolite of Scots pine seedlings for protection of deep-lying tissue against damaging UV-B, represents a typical acylated flavonol 3-O-glycoside. This compound was synthesized for the first time via two approaches. The first approach, starting with kaempferol, featured formation of the flavonol 3-O-glycosidic linkage with a glycosyl bromide under conventional PTC conditions. In the second approach, 5,7,4′-tri-O-benzyl- kaempferol was readily prepared from 2′,4′,6′- trihydroxyacetophenone and p-hydroxybenzoic acid, which was coupled with a glucopyranosyl o-hexynylbenzoate under the catalysis of a gold(I) complex to provide the desired 3-O-glycoside in excellent yield. A variety of the glycosyl o-hexanylbenzoates equipped with the 2-O-benzoyl group were also proven to be highly efficient donors for construction of the flavonol 3-O-glycosidic linkages.