124686-45-9

Upstream product

• 98-01-1 furfural 
• 124686-47-1 (4S,5S)-(+)-2,2-Dimethyl-5-methylamino-4-phenyl-1,3-dioxan 
• 151-50-8 potassium cyanide 

Downstream Products

• 124686-38-0 (R)-3-{(R)-Cyano-[((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-methyl-amino]-furan-2-yl-methyl}-heptanoic acid methyl ester 

Relevant academic research and scientific papers

Asymmetric nucleophilic acylation with metalated amino nitriles: Diastereo- and enantio-selective synthesis of 2-substituted 3-aroylcyclohexanones via tandem Michael addition/α-alkylation

Tandem conjugate addition/α-alkylation of lithiated chiral α-amino nitriles 3 and alkyl bromides to 2-cyclohexenone afforded 2-substituted 3-aroylcyclohexanones 5 of high diastereo- and enantiomeric purity (de ≥ 98%, ee ≥ 97 - ≥ 99%) and in good overall yields. The absolute configuration of the new stereogenic centres was determined by X-ray structure analysis of the Michael adduct 4c.