124691-91-4Relevant academic research and scientific papers
New strategy for the synthesis of chemically modified RNA constructs exemplified by hairpin and hammerhead ribozymes
El-Sagheer, Afaf H.,Brown, Tom
, p. 15329 - 15334 (2010)
The CuAAC reaction (click chemistry) has been used in conjunction with solid-phase synthesis to produce catalytically active hairpin ribozymes around 100 nucleotides in length. Cross-strand ligation through neighboring nucleobases was successful in covale
Synthesis of triazole-linked morpholino oligonucleotides via CuI catalysed cycloaddition
Palframan, Matthew J.,Alharthy, Rima D.,Powalowska, Paulina K.,Hayes, Christopher J.
, p. 3112 - 3119 (2016/03/19)
Triazole-linked morpholino (TLMO) oligonucleic acids were synthesised using the CuI catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase syn
