1246924-26-4

Basic information

• Product Name: 6-[3-(4-Chloro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-N-((S)-2,2,2-trifluoro-1-methyl-ethyl)-nicotinamide
• Synonyms: 6-[3-(4-Chloro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-N-((S)-2,2,2-trifluoro-1-methyl-ethyl)-nicotinamide
• CAS NO: 1246924-26-4
• Molecular Weight: 455.821
• Mol File: 1246924-26-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-[3-(4-Chloro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-N-((S)-2,2,2-trifluoro-1-methyl-ethyl)-nicotinamide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[3-(4-Chloro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-N-((S)-2,2,2-trifluoro-1-methyl-ethyl)-nicotinamide(1246924-26-4)
• EPA Substance Registry System: 6-[3-(4-Chloro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-N-((S)-2,2,2-trifluoro-1-methyl-ethyl)-nicotinamide(1246924-26-4)

Safety Data

• Hazardous Substances Data: 1246924-26-4(Hazardous Substances Data)

Upstream product

• 125278-10-6 (S)-1,1,1-trifluoropropan-2-amine 
• 1246924-74-2 6-[3-(4-chloro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-nicotinic acid 

Relevant articles and documents

SUBSTITUTED ISOXAZOLES

The present invention is concerned with novel hydroxy-methyl isoxazole derivatives of formula I wherein R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of the present invention have affinity and selectivity for GABA A α5 receptor. Further the present invention is concerned with the manufacture of the active compounds of formula I, pharmaceutical compositions containing them and their use as pharmaceuticals.