1246924-89-9

Upstream product

• 1239465-20-3 3-butyl-5-methyl-isoxazole-4-carboxylic acid ethyl ester 
• 5775-76-8 valeraldoxime 
• 1246924-88-8 3-butyl-5-([E]-styryl)-isoxazole-4-carboxylic acid 

Downstream Products

• 1254966-38-5 5-[3-butyl-5-(1,2-dihydroxy-2-phenyl-ethyl)-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 1246924-90-2 6-[3-butyl-5-([E]-styryl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester 

Relevant academic research and scientific papers

ISOXAZOLE-PYRAZOLE DERIVATIVES

The present invention is concerned with isoxazole-pyrazole derivatives of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.

SUBSTITUTED ISOXAZOLES

The present invention is concerned with novel hydroxy-methyl isoxazole derivatives of formula I wherein R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of the present invention have affinity and selectivity for GABA A α5 receptor. Further the present invention is concerned with the manufacture of the active compounds of formula I, pharmaceutical compositions containing them and their use as pharmaceuticals.