5775-76-8

Basic information

• Product Name: (E)-valeraldehyde oxime
• Synonyms: (E)-valeraldehyde oxime
• CAS NO: 5775-76-8
• Molecular Weight: 101.148
• Mol File: 5775-76-8.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: (E)-valeraldehyde oxime(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-valeraldehyde oxime(5775-76-8)
• EPA Substance Registry System: (E)-valeraldehyde oxime(5775-76-8)

Safety Data

• Hazardous Substances Data: 5775-76-8(Hazardous Substances Data)

Upstream product

• 110-62-3 pentanal 
• 110-58-7 n-Pentylamine 
• 628-05-7 1-nitropentane 
• 109-66-0 pentane 
• 3880-17-9 hexanoic nitrous anhydride 

Downstream Products

• 110-62-3 pentanal 
• 110-59-8 pentanonitrile 
• 110-58-7 n-Pentylamine 
• 2050-92-2 Di-n-amylamine 
• 626-97-1 pentamide 
• 14633-18-2 (3-butyl-isoxazol-5-yl)-methanol 
• 1239465-20-3 3-butyl-5-methyl-isoxazole-4-carboxylic acid ethyl ester 
• 1349699-37-1 3-n-butyl-5-(4-methylphenyl)-4,5-dihydroisoxazole 
• 1349699-52-0 3-butyl-5-(4-methylphenyl)-isoxazole 
• 1349699-35-9 5-(4-bromophenyl)-3-n-butyl-4,5-dihydroisoxazole 
• 1349699-51-9 5-(4-bromophenyl)-3-butyl-isoxazole 
• 1246924-89-9 [3-Butyl-5-([E]-styryl)-isoxazol-4-yl]-methanol 
• 1246924-88-8 3-butyl-5-([E]-styryl)-isoxazole-4-carboxylic acid 
• 1254966-38-5 5-[3-butyl-5-(1,2-dihydroxy-2-phenyl-ethyl)-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 

Relevant articles and documents

Exploring Heteroaromatic Rings as a Replacement for the Labile Amide of Antiplasmodial Pantothenamides

Malaria-causing Plasmodium parasites are developing resistance to antimalarial drugs, providing the impetus for new antiplasmodials. Although pantothenamides show potent antiplasmodial activity, hydrolysis by pantetheinases/vanins present in blood rapidly inactivates them. We herein report the facile synthesis and biological activity of a small library of pantothenamide analogues in which the labile amide group is replaced with a heteroaromatic ring. Several of these analogues display nanomolar antiplasmodial activity against Plasmodium falciparum and/or Plasmodium knowlesi, and are stable in the presence of pantetheinase. Both a known triazole and a novel isoxazole derivative were further characterized and found to possess high selectivity indices, medium or high Caco-2 permeability, and medium or low microsomal clearance in vitro. Although they fail to suppress Plasmodium berghei proliferation in vivo, the pharmacokinetic and contact time data presented provide a benchmark for the compound profile likely required to achieve antiplasmodial activity in mice and should facilitate lead optimization.

Amidyl Radical Directed Remote Allylation of Unactivated sp3 C?H Bonds by Organic Photoredox Catalysis

The development of visible-light-mediated allylation of unactivated sp3 C?H bonds is reported. The remote allylation was directed by the amidyl radical, which was generated by photocatalytic fragmentation of a pre-functionalized amide precursor. Both aromatic and aliphatic amide derivatives could successfully deliver the remote C?H allylation products in good yields. A variety of electron deficient allyl sulfone systems could be used as δ-carbon radical acceptor.

Rhodium(II)-Catalyzed Formal [3 + 2] Cycloaddition of N-Sulfonyl-1,2,3-triazoles with Isoxazoles: Entry to Polysubstituted 3-Aminopyrroles

A novel rhodium(II)-catalyzed formal [3 + 2] cycloaddition of N-sulfonyl-1,2,3-triazoles with isoxazoles has been achieved that provides an efficient method for the synthesis of polysubstituted 3-aminopyrrole derivatives. An operationally simple one-pot synthesis of the titled compounds from terminal alkynes, tosyl azide, and isoxazoles was also developed. The presented reaction affords an illustrative example of employing 1,2,3-triazoles as the [2C]-component in relevant cycloaddition reactions.