1246936-34-4

Upstream product

• 1246936-33-3 1-(4-fluoro-phenyl)-5-hydroxy-5-morpholin-4-yl-pentan-1-one 
• 100-39-0 benzyl bromide 

Downstream Products

• 1246936-35-5 5-benzyloxy-5-(4-fluoro-phenyl)pentanoic acid 
• 1478664-18-4 1-(4-fluoro-phenyl)-3-[3-(4-fluoro-phenyl)-3-hydroxy-propyl]-4-(4-hydroxy-phenyl)azetidin-2-one 

Relevant academic research and scientific papers

ENZYMATIC PROCESS FOR THE PREPARATION OF (S)-5-(4-FLUORO-PHENYL)-5-HYDROXY- 1MORPHOLIN-4-YL-PENTAN-1-ONE, AN INTERMEDIATE OF EZETIMIBE AND FURTHER CONVERSION TO EZETIMIBE

The present invention provides an enzymatic process for the preparation of (S)-5-(4-Fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one by the reduction of 1-(4-Fluoro-phenyl)-5-morpholin-4-yl-pentane-1,5-dione by using a suitable enzyme or by the resol