1246960-25-7

Usage

Uses

Used in Pharmaceutical Research:
(R)-3-(((Benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs targeting specific biological processes, potentially leading to novel treatments for various diseases.
Used in Chemical Research:
In the field of chemical research, (R)-3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid serves as a valuable compound for studying the effects of structural modifications on chemical and biological properties. This can lead to a better understanding of molecular interactions and the development of new chemical entities with improved characteristics.
Used in Drug Delivery Systems:
(R)-3-(((Benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid can be utilized in the development of drug delivery systems, where its unique structure may enhance the solubility, stability, or targeted delivery of therapeutic agents. This application can improve the bioavailability and efficacy of drugs, leading to more effective treatments for patients.
Used in Biochemical Studies:
As a member of the amino acid family, (R)-3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid can be employed in biochemical studies to investigate its interactions with proteins and other biomolecules. This research can provide insights into the role of amino acids in biological processes and contribute to the development of new therapeutic strategies.

Upstream product

• 100-51-6 benzyl alcohol 
• 651047-33-5 3-(2,4,5-trifluorophenyl)propanoic acid 
• 1407666-61-8 (R)-t-butyl 4-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-3-(2,4,5-trifluorobenzyl)butanoate 
• 1407666-67-4 (R)-4-(t-butoxy)-4-oxo-2-(2,4,5-trifluorobenzyl)butanoic acid 
• 1407666-72-1 (R)-tert-butyl 3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate 
• 1407666-56-1 (S)-4-benzyl-3-(3-(2,4,5-trifluorophenyl)propanoyl)oxazolidin-2-one 
• 769195-26-8 4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester 
• 1361050-75-0 methyl (R)-3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate 
• 1102373-43-2 C₉H₆ClF₃O 
• 1407666-69-6 C₁₅H₁₆F₃NO₃ 
• 1246960-16-6 (S)-1-azido-3-(2,4,5-trifluorophenyl)propane-2-ol 
• 502462-00-2 (2,4,5-trifluorophenyl)-magnesium bromide 
• 1246960-24-6 (R)-benzyl 1-cyano-3-(2,4,5-trifluorophenyl)propane-2-ylcarbamate 
• 1246960-18-8 (R)-benzyl 2-(2,4,5-trifluorobenzyl)aziridine-1-carboxylate 

Downstream Products

• 1361050-75-0 methyl (R)-3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate 
• 486460-32-6 sitagliptin 
• 1242069-63-1 (R)-benzyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate 

Relevant academic research and scientific papers

Glucovance west Geleg sandbank intermediate process for the preparation of amino acid derivatives

The invention discloses a preparation method of a new diabetes drug sitagliptin intermediate aminobenzene butyric acid derivative. The preparation method comprises the following steps of: (1) mixing a compound shown in a formula I with R(+)-alpha-phenethyl and acetic acid to obtain a compound shown in a formula II; (2) mixing the compound shown in the formula II with sodium borohydride and protonic acid or lewis acid to obtain a compound shown in a formula III; (3) mixing the compound shown in the formula III with X to obtain a compound shown in a formula IV; (4) mixing the compound as shown in the formula IV with an inorganic base 1 to obtain a compound shown in a formula V; (5) obtaining a compound shown in a formula VI by the compound shown in the formula V; and (6) mixing the compound shown in the formula VI with an inorganic base 2 to obtain a compound shown in a formula VII.

PROCESS FOR THE PRODUCTION OF SITAGLIPTIN

A novel process is described for the synthesis of Sitagliptin, IUPAC name 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine, of formula (I).

PROCESS FOR THE PRODUCTION OF SITAGLIPTIN

A novel process is described for the synthesis of Sitagliptin, lUPAC name 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1 2,4-triazolo[4,3-a]pyrazine, of formula (I).

METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE

The present invention relates to an improved method for preparing dipeptidyl peptidase-IV inhibitor and intermediate. The present invention is able to reduce preparation costs by using low cost reagents on reaction and is able to be used in mass production by improving yield.

Process for the production of sitagliptin

The present invention is directed to a process for the preparation of Sitagliptin, having formula (I)

METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE

The present invention relates to an improved method for manufacturing dipeptidyl peptidase-IV inhibitor and intermediate. The present invention allows reduction of production costs by reacting low cost reagents, improves yield and is adaptable for mass production.