1246993-51-0Relevant articles and documents
Bisphosphonate-functionalized cyclic Arg-Gly-Asp peptidomimetics
Drago, Carmelo,Arosio, Daniela,Casagrande, Cesare,Manzoni, Leonardo
, p. 185 - 200 (2013/01/16)
We report the synthesis of three new conjugates between a cRGD integrin ligand and alendronic acid as a bisphosphonate anchor. The selected ligand is an RGD peptidomimetic, carrying the conformationally constrained RGD sequence on an azabicycloalkane scaf
Chemoselective attachment of small molecule effector functionality to human adenoviruses facilitates gene delivery to cancer cells
Banerjee, Partha Sarathi,Ostapchuk, Philomena,Hearing, Patrick,Carrico, Isaac
supporting information; experimental part, p. 13615 - 13617 (2010/12/19)
We demonstrate here a novel two-step "click" labeling process in which adenoviral particles are first metabolically labeled during production with unnatural azido sugars. Subsequent chemoselective modification allows access to viruses decorated with a broad array of effector functionality. Adenoviruses modified with folate, a known cancer-targeting motif, demonstrated a marked increase in gene delivery to a murine cancer cell line.