927888-44-6

Basic information

• Product Name: 4,7,10-Trioxa-14-azapentadecan-1-amine, 15,15,15-triphenyl-
• CAS NO: 927888-44-6
• Molecular Formula: C29H38N2O3
• Molecular Weight: 462.632
• Mol File: 927888-44-6.mol

Chemical Properties

• CAS DataBase Reference: 4,7,10-Trioxa-14-azapentadecan-1-amine, 15,15,15-triphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4,7,10-Trioxa-14-azapentadecan-1-amine, 15,15,15-triphenyl-(927888-44-6)
• EPA Substance Registry System: 4,7,10-Trioxa-14-azapentadecan-1-amine, 15,15,15-triphenyl-(927888-44-6)

Safety Data

• Hazardous Substances Data: 927888-44-6(Hazardous Substances Data)

Upstream product

• 4246-51-9 4,7,10-trioxa-1,13-diaminotridecane 
• 76-83-5 trityl chloride 

Downstream Products

• 1246993-51-0 C₃₄H₄₂N₂O₄ 
• 1419872-67-5 C₅₅H₈₅N₁₃O₁₈S 
• 183896-00-6 N-(13-amino-4,7,10-trioxatridecanyl)-D-biotinamide 
• 1026991-73-0 C₇₀H₁₁₃N₃O₉ 
• 1349068-55-8 C₄₈H₅₃ClN₆O₄S 
• 959924-11-9 4-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyloxy)-(Z)-but-2-enyloxycarbonyl-(3-(2-(2-(3-(trityl-amino)-propoxy)-ethoxy)-ethoxy)propyl)-amine 

Relevant articles and documents

Polypeptides with High Zwitterion Density for Safe and Effective Therapeutics

The commonly used “stealth material” poly(ethylene glycol) (PEG) effectively promotes the pharmacokinetics of therapeutic cargos while reducing their immune response. However, recent studies have suggested that PEG could induce adverse reactions, including the emergence of anti-PEG antibodies and tissue histologic changes. An alternative stealth material with no or less immunogenicity and organ toxicity is thus urgently needed. We designed a polypeptide with high zwitterion density (PepCB) as a stealth material for therapeutics. Neither tissue histological changes in liver, kidney, or spleen, nor abnormal behavior, sickness or death was induced by the synthesized polymer after high-dosage administration for three months in rats. When conjugated to a therapeutic protein uricase, the uricase–PepCB bioconjugate showed significantly improved pharmacokinetics and immunological properties compared with uricase–PEG conjugates.

Binding cofactors with triplex-based DNA motifs

Cofactors are pivotal compounds for the cell and many biotechnological processes. It is therefore interesting to ask how well cofactors can be bound by oligonucleotides designed not to convert but to store and release these biomolecules. Here we show that triplex-based DNA binding motifs can be used to bind nucleotides and cofactors, including NADH, FAD, SAM, acetyl CoA, and tetrahydrofolate (THF). Dissociation constants between 0.1μM for SAM and 35μM for THF were measured. A two-nucleotide gap still binds NADH. The selectivity for one ligand over the others can be changed by changing the sequence of the binding pocket. For example, a mismatch placed in one of the two triplets adjacent to the base-pairing site changes the selectivity, favoring the binding of FAD over that of ATP. Further, changing one of the two thymines of an A-binding motif to cytosine gives significant affinity for G, whereas changing the other does not. Immobilization of DNA motifs gives beads that store NADH. Exploratory experiments show that the beads release the cofactor upon warming to body temperature. Copyright

Bisphosphonate-functionalized cyclic Arg-Gly-Asp peptidomimetics

We report the synthesis of three new conjugates between a cRGD integrin ligand and alendronic acid as a bisphosphonate anchor. The selected ligand is an RGD peptidomimetic, carrying the conformationally constrained RGD sequence on an azabicycloalkane scaf