124705-61-9

Upstream product

• 124705-61-9 6H-Pyrrolo[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6-one, 5,5a,7,8,8a,9-hexahydro-9-[(4,6-O-ethylidene-β-D-glucopyranosyl)oxy]-5-[(4-hydroxy-3,5-dimethoxy)phenyl]-7-[(phenylmethylene)amino][5R-[5α,5aβ,8aα,9β(R*)]- 
• 33419-42-0 etoposide 
• 124705-76-6 C₃₆H₄₀N₂O₁₃ 
• 124816-28-0 (5R,6R,7R,8S)-8-((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-7-hydroxymethyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid hydrazide 

Downstream Products

• 124705-63-1 (5R,5aR,8aR,9S)-9-((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-5,5a,7,8,8a,9-hexahydro-1,3-dioxa-7-aza-dicyclopenta[b,g]naphthalen-6-one 
• 124705-62-0 (5R,5aR,8aR,9S)-7-Benzylamino-9-((2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-5,5a,7,8,8a,9-hexahydro-1,3-dioxa-7-aza-dicyclopenta[b,g]naphthalen-6-one 
• 124705-61-9 C₃₆H₃₈N₂O₁₂ 

Relevant academic research and scientific papers

Epipodophyllotoxin glucoside lactam derivatives

Novel antitumor epipodophyllotoxin glucoside lactam derivatives are prepared by first converting the lactone ring of the parent compound to the open-chain trans-hydroxy hydrazide, condensing the hydrazide with a carbonyl compound to form the corresponding hydrazone, and finally cyclizing the trans-hydroxy hydrazone using diethylazodicarboxylate and triphenylphosphine.

SYNTHESIS OF ETOPOSIDE LACTAM VIA A MITSUNOBU REACTION SEQUENCE

A novel chemical sequence for the conversion of a lactone antitumor agent 1 (etoposide) to the corresponding lactam 2 is described.The key steps involve a Mitsunobu cyclization (Ph3P, DEAD) of the γ-hydroxymethyl acyl benzaldehyde hydrazone 6 to a lactam derivative 7 followed by reductive cleavage (Ra-Ni) to lactam 2.