1247338-10-8

Basic information

• Product Name: (3-(dihydroxyboranyl)benzyl)triphenylphosphanium
• Synonyms: (3-(dihydroxyboranyl)benzyl)triphenylphosphanium
• CAS NO: 1247338-10-8
• Molecular Weight: 397.241
• Mol File: 1247338-10-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3-(dihydroxyboranyl)benzyl)triphenylphosphanium(CAS DataBase Reference)
• NIST Chemistry Reference: (3-(dihydroxyboranyl)benzyl)triphenylphosphanium(1247338-10-8)
• EPA Substance Registry System: (3-(dihydroxyboranyl)benzyl)triphenylphosphanium(1247338-10-8)

Safety Data

• Hazardous Substances Data: 1247338-10-8(Hazardous Substances Data)

Upstream product

• 51323-43-4 (3-(bromomethyl)phenyl)boronic acid 
• 603-35-0 triphenylphosphine 

Relevant articles and documents

Preparation and biological evaluation of radioiodine-labeled triphenylphosphine derivatives as mitochondrial targeting probes

The positive-charged lipophilic triphenylphosphonium cations (TPPs+) have been served as mitochondrial targeting vehicles for the delivery of various probes. In this study, we developed a new method for the preparation of radioiodine-labeled TPPs+. Four 125I-labeled TPPs+, [125I] 9–[125I] 12, were prepared from the corresponding triphenylphosphine phenylborate precursors of B 5–B 8 via an optimized copper-catalyzed one-step procedure in high radiochemical yield (>95%). After radio-HPLC purification, the final products could be obtained with high specific activity. Their physicochemical properties, in vitro cellular uptake, and ex vivo mice biodistribution were investigated. The results suggested the 125I-labeled TPPs+ were lipophilic and could specifically accumulate in the mitochondrial-rich myocardial cells through the mitochondrial membrane potential.