51323-43-4

Basic information

• Product Name: 3-Bromomethylphenylboronic acid
• Synonyms: 3-(BROMOMETHYL)BENZENEBORONIC ACID;3-BROMOMETHYLPHENYLBORONIC ACID;M-(BROMOMETHYL)PHENYLBORONIC ACID;RARECHEM AH PB 0062;3-Boronobenzyl bromide~3-(Bromomethyl)phenylboronic acid;3-Bromomethylphenylboronic;3-boronobenzyl bromide;3-BROMOMETHYLPHENYLBORONIC ACID 96%
• CAS NO: 51323-43-4
• Molecular Formula: C₇H₈BBrO₂
• Molecular Weight: 214.85
• EINECS: 1308068-626-2
• Product Categories: blocks;BoronicAcids;Bromides;Boronic acids;Boronic acid;Aryl;Boronic Acids;Boronic Acids and Derivatives;Organoborons;Aryl Boronic Acids;Boronic Acids and Derivatives;Chemical Synthesis;Monosubstituted Aryl Boronic Acids;Organometallic Reagents
• Mol File: 51323-43-4.mol

Chemical Properties

• Melting Point: 214-216°C
• Boiling Point: 359.1 °C at 760 mmHg
• Flash Point: 171 °C
• Appearance: White to tan/Crystalline Powder
• Density: 1.57 g/cm³
• Vapor Pressure: 8.83E-06mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• PKA: 8.11±0.10(Predicted)
• BRN: 3246618
• CAS DataBase Reference: 3-Bromomethylphenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromomethylphenylboronic acid(51323-43-4)
• EPA Substance Registry System: 3-Bromomethylphenylboronic acid(51323-43-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 34-36/37/38-20/21/22
• Safety Statements: 26-36/37/39-45-36
• RIDADR: 3261
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: II
• Hazardous Substances Data: 51323-43-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromomethylphenylboronic acid is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its application is primarily due to its reactivity in the Suzuki reaction, which allows for the formation of complex molecular structures with potential therapeutic properties.
Used in Materials Science:
In the field of materials science, 3-Bromomethylphenylboronic acid is utilized as a precursor for the development of novel materials with specific properties. Its involvement in the Suzuki reaction enables the creation of new materials with tailored characteristics, such as improved mechanical strength, thermal stability, or electrical conductivity.
Used in Chemical Research:
3-Bromomethylphenylboronic acid is also employed as a research tool in organic chemistry, particularly for studying the Suzuki reaction and its applications in the synthesis of complex organic molecules. 3-Bromomethylphenylboronic acid provides valuable insights into the reaction mechanisms and helps in the development of more efficient and selective synthetic methods.

InChI:InChI=1/C7H8BBrO2/c9-5-6-2-1-3-7(4-6)8(10)11/h1-4,10-11H,5H2

Upstream product

• 17933-03-8 m-tolylboronic acid 
• 128-08-5 N-Bromosuccinimide 
• 625-95-6 3-Iodotoluene 

Downstream Products

• 397843-58-2 [3-(morpholin-4-ylmethyl)phenyl]boronic acid 
• 4261-14-7 9-benzyl-9H-purin-6-ylamine 
• 849417-16-9 (CH₃)2NC₆H₄CHCHC₅H₄NCH₂C₆H₄B(OH)2⁽¹⁺⁾*Br^(1-)=(CH₃)2NC₆H₄CHCHC₅H₄NCH₂C₆H₄B(OH)2Br 
• 1379545-29-5 [3-({[4-bromo-1-(2,2-dimethylpropyl)-1H-1,2,3-benzotriazol-5-yl]oxy}methyl)phenyl]boronic acid 
• 1225280-17-0 7-[3-(pyrrolidin-1-ylmethyl)phenyl]pyrido[3,4-b]pyrazine 
• 1011531-81-9 3-((4-((S)-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-1-(isoxazol-3-yl)-3-oxopropyl)phenoxy)methyl)phenylboronic acid 

Relevant articles and documents

Synthesis of (azidomethyl)phenylboronic acids

The synthesis of 2-, 3-, and 4-(azidomethyl)phenylboronic acids was carried out. The geometric and electronic structures were studied by quantum-chemical methods. The suggestion is made that there are weak intramolecular interactions between the boron atom and the nitrene nitrogen atom of the azido group.

FLUORESCENT COMPOUND AND PREPARATION METHOD AND USE FOR THE SAME

Disclosed is a fluorescent compound as represented by general formula I, or a salt, an enantiomer, a diastereomer, a tautomer, a solvate or a polymorph thereof, having the structure (I); wherein m and n are each an integer between 0-10; and Y1 and Y2 are each independently selected from the group of hydrogen, phenyl, hydroxyl, carboxyl, an ester group, a boric acid group, a borate group, and a 3 to 7 membered ring substituted with one or more boric acid groups or borate groups, and at least one of Y1 and Y2 is a boron-containing group. The compound has the characteristics of a high fluorescence intensity and a high sensitivity.

Fluorescent compound and preparation method and application thereof

The invention discloses a fluorescent compound and a preparation method and application thereof. The fluorescent compound is shown in a general formula I, and the structure of the compound of the formula I is as shown in the description of the fluorescent compound, wherein m and n are each independently an integer from 0-10; and Y and Y are each independently selected from a following group:hydrogen, phenyl, hydroxyl, carboxyl, an ester group, a boric acid group, a boric acid ester group and one or more boric acid group or boric acid ester group substituted 3-7 membered rings, and at least one of Y and Y is a boracic group. The fluorescent compound has the characteristics of high fluorescence intensity and high sensitivity.

Indole and quinoline derivatives and its preparation method and application

The invention provides an indoloquinoline derivative, a preparation method and application thereof in preparing antitumor drugs and antiviral drugs. The chemical structure of the indoloquinoline derivative is shown as a formula I. Experiments show that a partly-boric-acid-modified indoloquinoline derivative and a non-boric-acid-modified indoloquinoline derivative have strong inhibition effect on various tumor cell strains, thereby being capable of being used for preparation of the antitumor drugs, and have strong antiviral activity, thereby being capable of being used for preparation of the antiviral drugs.