124745-48-8Relevant academic research and scientific papers
Evaluation of the antitrypanosoma activity and SAR study of novel LINS03 derivatives
Varela, Marina T.,Costa-Silva, Thais A.,Lago, Jo?o Henrique G.,Tempone, Andre G.,Fernandes, Jo?o Paulo S.
, (2019)
Chagas’ disease is a parasitic infection caused by Trypanosoma cruzi that is still treated by old and toxic drugs. In the search for novel alternatives, natural sources are an important source for new drug prototypes against T. cruzi to further structural
Highly selective catalytic intermolecular reductive coupling of alkynes and aldehydes
Huang, Wei-Sheng,Chan, Johann,Jamison, Timothy F.
, p. 4221 - 4223 (2000)
(aquation presented) Alkynes (internal and terminal) and aldehydes (aromatic and aliphatic) are reductively coupled in a single catalytic reaction to yield di- and trisubstituted allylic alcohols with high stereoselectivity and regioselectivity. In most cases, a 1:1 ratio of alkyne to aldehyde is sufficient for efficient coupling. The yield and regioselectivity are strongly dependent on the phosphine ligand, but the allylic alcohols formed are invariably the products of cis addition to the alkyne.
