124753-38-4

Upstream product

• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 17331-53-2 3'-O-benzoylthymidine 
• 120942-89-4 Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester bis-(2,2,2-trifluoro-1-trifluoromethyl-ethyl) ester 
• 115244-23-0 C₅₅H₅₃N₄O₁₅P 
• 102987-86-0 C₄₈H₄₉N₄O₁₄P 

Relevant academic research and scientific papers

Nucleoside Phosphite, 0-Bis(1,1,1,3,3,3-hexafluoro-2-propyl) Deoxyribonucleosid-3'-yl Phospites. A Versatile Synthetic Intermediate for Phosphonate Modified Nucleotide and Oligonucleotide Synthesis

The 0-bis(1,1,1,3,3,3-hexa-fluoro-2-propyl) deoxyribonucleosid-3'-yl phosphite units could be converted into the 0-nucleosid-3'-yl phosphonate, 0-2-cyanoethyl 0-nucleosid-3'-yl phosphonate, and 0-1,1,1,3,3,3-hexafluoro-2-propyl 0-nucleosid-3'yl phosphonot

Nucleoside H-Phosphonates. 13. Studies on 3H-1,2-Benzodithiol-3-one Derivatives as Sulfurizing Reagents for H-Phosphonate and H-Phosphonothioate Diesters

Formation of O-oxidized products during sulfurization of H-phosphonothioate and H-phosphonate diesters with 3H-1,2-benzodithiol-3-one 1,1-dioxide (1) was found to be due to generation of the O-oxidizing agents, most likely 3H-2,1-benzoxathiol-3-one 1-oxide (4) and 3H-2,1-benzoxathiol-3-one (5), during the course of the reactions.Another source of the side products formation may be the disproportionation of 1 that occurs in the presence of triethylamine.To overcome these problems, a new sulfur-transferring reagent, 3H-1,2-benzodithiol-3-one (3), has been developed.Under aqueous reaction conditions, which are compartible with both solution and solid-phase synthesis of oligonucleotides, the reagent 3 furnished clean and fast conversion of H-phosphonothioate and H-phosphonate diesters into the corresponding phosphorodi- and phosphoromonothioates.

ACYLPHOSPHONATES. 7. A NEW METHOD FOR STEREOSPECIFIC AND STEREOSELECTIVE GENERATION OF DIDEOXYRIBONUCLEOSIDE PHOSPHOROTHIOATES VIA THE ACYLPHOSPHONATE INTERMEDIATES

Dideoxyribonucleoside phosphorothioates were synthesized by a new method via dideoxyribonucleoside 2,2,2-trichloroethoxycarbonylphosphonates and aroylphosphonates.The conversion of dideoxyribonucleoside 2,2,2-trichloroethoxycarbonylphosphonates to dideoxy