102987-86-0

Upstream product

• 17331-53-2 3'-O-benzoylthymidine 
• 50571-26-1 5'-O-dimethoxytritylthymidine 3'-H-phosphonate 
• 104655-84-7 5‘-O-dimethoxytrityl-2’-deoxyribothymidine 3‘-O-phosphorodiamidite 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 120942-89-4 Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester bis-(2,2,2-trifluoro-1-trifluoromethyl-ethyl) ester 
• 130288-81-2 5'-O-dimethoxytrityl-2'-deoxythymidine-3'-H-phosphonate 
• 104655-86-9 C₅₄H₆₂N₅O₁₃P 

Downstream Products

• 124753-38-4 C₄₈H₄₉N₄O₁₄PS 

Relevant academic research and scientific papers

USE OF NEW PHOSPHONYLATING AND COUPLING AGENTS IN THE SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDES VIA THE H-PHOSPHONATE APPROACH

Tris(1,1,1,3,3,3-hexafluoro-2-propyl) phosphite was used as a phosphonylating reagent for the preparation of nucleoside 3'-H-phosphonate units.The use of a new coupling reagent, 1,3-dimethyl-2-chloro-imidazolinium chloride (DMCI) for the internucleotidic H-phosphonate bond formation via the H-phosphonate approach is also discussed in detail.

BISPENTAFLUOROPHENYL CARBONATE IN THE SYNTHESIS OF OLIGONUCLEOTIDES BY THE H-PHOSPHONATE METHOD

Key words: oligonucleotide synthesis; H-phosphonate method; condensing reagent.

A NEW AND VERSATILE APPROACH TO THE PREPARATION OF VALUABLE DEOXYNUCLEOSIDE 3'-PHOSPHITE INTERMEDIATES

The easily accessible and crystalline monofunctional phosphitylating reagent bis-(diisopropylamino)chlorophosphine has been used for the synthesis of phosphoramidites and H-phosphonates of d-nucleosides and, also, the formation of 3'-5'-internucleotidic phosphonate bonds.