1248010-13-0Relevant academic research and scientific papers
Domino [Pd]-Catalysis: One-Pot Synthesis of Isobenzofuran-1(3H)-ones
Mahendar, Lodi,Satyanarayana, Gedu
, p. 7685 - 7691 (2016)
An efficient domino [Pd]-catalysis for the synthesis of isobenzofuran-1(3H)-ones is presented. The strategy shows broad substrate scope and is amenable to o-bromobenzyl tertiary/secondary/primary alcohols. Significantly, the method was applied to the synthesis of antiplatelet drug n-butyl phthalide and cytotoxic agonist 3a-[4′-methoxylbenzyl]-5,7-dimethoxyphthalide.
Borylation of Olefin C-H Bond via Aryl to Vinyl Palladium 1,4-Migration
Hu, Tian-Jiao,Zhang, Ge,Chen, Ya-Heng,Feng, Chen-Guo,Lin, Guo-Qiang
supporting information, p. 2897 - 2900 (2016/03/19)
The aryl to vinyl palladium 1,4-migration was realized for the first time. The generated alkenyl palladium species was trapped by diboron reagents under Miyaura borylation conditions, providing a new method to synthesize β,β-disubstituted vinylboronates. The excellent regioselectivity and broad substrate scope were observed for this novel transformation.
Cu-MEDIATED ANNULATION FOR THE EFFECTIVE SYNTHESIS OF 3-SUBSTITUTED PHTHALIDES
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Page/Page column 0081; 0082; 0092, (2015/02/25)
The present invention disclosed herein is a novel commercially feasible, one pot synthesis of library of 3-substituted phthalides of formula I via CuCN mediated oxidative cyclization in high yield. Formula I
Cu-MEDIATED ANNULATION FOR THE EFFECTIVE SYNTHESIS OF 3-SUBSTITUTED PHTHALIDES
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Page/Page column 15, (2013/07/19)
The present invention disclosed herein is a novel commercially feasible, one pot synthesis of library of 3-substituted phthalides of formula I via CuCN mediated oxidative cyclization in high yield. Formula I
