124818-93-5

Upstream product

• 124818-94-6 ethyl (2E,4S)-4-[(tert-butoxycarbonyl)amino]-5-phenylpent-2-enoate 
• 72155-45-4 Boc-L-phenylalaninal 
• 87694-53-9 Boc-Phe-OH N,O-dimethyl hydroxamate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 

Downstream Products

• 188000-27-3 (E,4S)-4-[(tert-butoxycarbonyl)amino]-5-phenyl-2-pentenyl methanesulfonate 
• 188000-32-0 tert-butyl N-[(1S,2E)-1-benzyl-4-thiocyanato-2-butenyl]carbamate 
• 188000-37-5 tert-butyl (4S,5S)-5-benzyl-2-thioxo-4-vinyltetrahydro-1H-1-imidazolecarboxylate 
• 298208-76-1 (4S-trans)-4,5-dihydro-4-benzyl-2-phenyloxazoline-5-acetic Acid 
• 257296-71-2 (4S-trans)-4,5-dihydro-4-benzyl-5-(2-hydroxyethyl)-2-phenyloxazoline 
• 208935-28-8 (4S-trans)-4,5-dihydro-4-benzyl-2-phenyl-5-vinyloxazoline 
• 257296-59-6 (-)-N-((2S,3S)-3-hydroxy-1-phenyl-4-pentenyl)benzamide 
• 303766-36-1 N-((E)-(S)-1-Benzyl-4-hydroxy-but-2-enyl)-benzamide 
• 257296-53-0 N-((2S)-5-acetoxy-1-phenyl-3-butenyl)benzamide 
• 885859-80-3 (3S,4S)-4-Amino-5-phenyl-pentane-1,3-diol 
• 124915-64-6 (4S,5R)-5-ethenyl-4-phenylmethyloxazolidin-2-one 
• 114671-12-4 (4S,5S)-5-ethenyl-4-phenylmethyloxazolidin-2-one 
• 114671-09-9 N-(tert-butyldimethylsilyloxycarbonyl)-4-amino-1-chloro-5-phenyl-2-pentene 
• 72155-48-7 (3S,4S)-4-tert-butoxycarbonylamino-3-hydroxy-5-phenylpentanoic acid 

Relevant academic research and scientific papers

Highly stereoselective intramolecular SN2′ cyclization yielding chiral oxazolidin-2-ones: General route to α-hydroxy-β-amino acids

Intramolecular nucleophilic attack onto allylsulfonates promoted by silica gel acting as an acid catalyst provides expedient stereoselective access to 4,5-difunctionalized oxazolidin-2-ones. Precursors were prepared efficiently from enantiopure α-amino ac

Stereoselective intramolecular cyclization of allyl and homoallyl benzamide via π-allylpalladium complex catalyzed by Pd(0)

The transformation of acyclic allylic benzamides 4 and homoallylic benzamides 12 to vinyl oxazolines 3 is achieved in the presence of base by the catalysis and Pd(0) in high yield and with high diastereoselectivity. Especially, in the case of homoallylic benzamides 12, trans-oxazolines 3 are formed exclusively or predominantly over cis-oxazolines 8, irrespective of the composition of their stereoisomers. The reaction is believed to proceed via the same π-allylpalladium complex that arises from either primary or secondary allylic acetates. We applied this method to the syntheses of β- amino-α-hydroxy acids 1 and γ-amino-β-hydroxy acids 2, conveniently protected as oxazoline.

Irreversible inhibitions of serine proteases by peptidyl allylic halide derivatives

Peptidyl 4-amino-5-phenyl-2-pentenyl bromide (7a, 9a, 10a) and chloride derivatives (7b, 9b, 10b) were found to be active-site directed irreversible inhibitors of α-chymotrypsin but did not show any irreversible inhibitory activity toward porcine pancreatic elastase. Copyright

A stereoselective approach to the synthesis of aminoalcohols

Amino alkoxy oxiranes have been isomerized to stereochemically pure amino alcohols, useful precursors for dipeptides isosteres, by treatment with the superbasic mixture butyllithium/diisopropylamine/potassium tert-butoxide.

Stereoselective Syntheses of α-Hydroxy-γ-amino Acids: Possible γ-Turn Mimetics

Enantiomerically pure 4-amino-allyloxy-acetates, prepared from L-amino acids, undergo a stereoselective Wittig rearrangement with formation of the corresponding α-hydroxy-γ-amino acid esters having γ-turn conformational features.

Syntheses and reactions of silyl carbamates. 2. A new mode of cyclic carbamate formation from tert-butyldimethylsilyl carbamate

Stereoselective construction of 1,2 and 1,3 amino hydroxyl systems was achieved by the intramolecular trapping of the N-tert-butyldimethylsilyloxycarbonyl species (silyl carbamate) activated by fluoride ion. The reaction of the silyl carbamate with 1,2-sy

A NEW MODE OF CYCLIC CARBAMATE FORMATION VIA tert.-BUTYLDIMETHYLSILYL CARBAMATE. STEREOSELECTIVE SYNTHESES OF STATINE AND ITS ANALOGUE

Stereoselective construction of 1,2- and 1,3-amino hydroxyl systems was carried out using SN2' (initiated by AgF or AgF-Pd(II)) cyclic carbamate formations from tert.-butyldimethyl silyl carbamates.This method was applied to the syntheses of st