1248341-66-3Relevant academic research and scientific papers
Intramolecular azide to alkene cycloadditions for the construction of pyrrolobenzodiazepines and azetidino-benzodiazepines
Hemming, Karl,Chambers, Christopher S.,Jamshaid, Faisal,O'Gorman, Paul A.
, p. 16737 - 16756 (2015/01/09)
The coupling of proline- and azetidinone-substituted alkenes to 2-azidobenzoic and 2-azidobenzenesulfonic acid gives precursors that undergo intramolecular azide to alkene 1,3-dipolar cycloadditions to give imine-, triazoline- or aziridine-containing pyrr
Azide based routes to tetrazolo and oxadiazolo derivatives of pyrrolobenzodiazepines and pyrrolobenzothiadiazepines
Hemming, Karl,Chambers, Christopher S.,Hamasharif, Muslih S.,Jo?o, Heidi,Khan, Musharraf N.,Patel, Nilesh,Airley, Rachel,Day, Sharn
, p. 7306 - 7317 (2016/02/03)
Tetrazolo- and 1,2,4-oxadiazolo-fused derivatives of the antitumour, antibiotic, DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines and their pyrrolobenzothiadiazepine derivatives have been produced as analogues of a 1,2,3-triazolo-fused pyrrolobenzothiad
Intramolecular 1,3-dipolar cycloaddition as a route to triazolobenzodiazepines and pyrrolobenzodiazepines
Chambers, Christopher S.,Patel, Nilesh,Hemming, Karl
scheme or table, p. 4859 - 4861 (2010/10/02)
Intramolecular 1,3-dipolar cycloaddition between an alkyne and an azide leads to a series of 1,2,3-triazolo-fused 1,4-benzodiazepines, 1,2,5-benzothiadiazepines, pyrrolobenzodiazepines and pyrrolobenzothiadiazepines (eight examples). The products are priv
