71236-07-2

Upstream product

• 88-21-1 2-amino-1-benzenesulfonic acid 

Downstream Products

• 203932-90-5 2-azidobenzenesulfonyl chloride 
• 1248341-71-0 C₁₁H₁₆N₄O₃S 
• 1248341-73-2 C₁₅H₁₆N₄O₃S 
• 1248341-66-3 (S)-(1-(2'-azidobenzenesulfonyl)pyrrolidin-2-yl)methanol 
• 1394932-03-6 C₁₅H₁₂N₄O₂S 
• 1394932-07-0 C₁₅H₁₁ClN₄O₂S 
• 1394932-08-1 C₁₆H₁₃ClN₄O₂S 
• 1394932-09-2 C₁₆H₁₄N₄O₂S 
• 1394932-10-5 C₁₇H₁₆N₄O₂S 
• 1394932-11-6 C₁₆H₁₄N₄O₃S 
• 1394932-12-7 C₁₆H₁₄N₄O₂S 
• 1394932-06-9 2-azido-N-(2-oxo-2H-chromen-6-yl)benzenesulfonamide 
• 203932-93-8 2-azido-N-(4-methylphenyl)benzenesulfonamide 
• 203932-95-0 2-azido-N-(4-methoxyphenyl)benzenesulfonamide 

Relevant academic research and scientific papers

Facile synthesis of benzothiadiazine 1,1-dioxides, a precursor of RSV inhibitors, by tandem amidation/ intramolecular aza-Wittig reaction

Reaction of o-azidobenzenesulfonamides with ethyl carbonochloridate afforded the corresponding amide derivatives, which gave 3-ethoxy-1,2,4- benzothiadiazine 1,1-dioxides through an intramolecular aza-Wittig reaction. The reaction was found to be general

Chelation-Assisted Interrupted Copper(I)-Catalyzed Azide-Alkyne-Azide Domino Reactions: Synthesis of Fully Substituted 5-Triazenyl-1,2,3-triazoles

We describe the synthesis of 1,4-(disubstituted)-5-triazenyl-1,2,3-triazoles through a ligand-free domino copper(I)-catalyzed azide-alkyne-azide process of chelating aryl azides bearing N-P═O, P═O, and SO3H groups at the ortho position with a wide variety of acetylenes. DFT calculations reveal that Cu-chelation is a crucial factor in the interception of the CuAAC intermediate by the azide. The crystal structure of the catalytic species has been determined by X-ray diffraction.

Synthesis and spectral properties of 6′-triazolyl-dihydroxanthene-hemicyanine fused near-infrared dyes

We describe the synthesis of a range of 6′-triazolyl-dihydroxanthene-hemicyanine (DHX-hemicyanine) fused dyes through an effective copper-catalyzed azide-alkyne cycloaddition (CuAAC) "click"reaction, with the aim of providing molecular diversity and evaluating the spectral properties of these near-infrared (NIR)-active materials. This was implemented by reacting 15 different aliphatic and aromatic azides with a terminal alkynyl-based DHX-hemicyanine hybrid scaffold prepared in four steps and 35% overall yield from 4-bromosalicylaldehyde. The resulting triazole derivatives have been fully characterized and their optical properties determined both in organic solvents and under simulated physiological conditions (phosphate buffered saline containing 5% of bovine serum albumin protein). This systematic study is a first important step towards the development of NIR-I fluorogenic "click-on"dyes or related photoactive agents for light-based diagnostic and/or therapeutic applications.

An one-pot approach to the synthesis of triazolobenzothiadiazepine 1,1-dioxide derivatives by basic alumina-supported azide-alkyne [3+2] cycloaddition

An efficient one-pot strategy for the synthesis of triazolobenzothiadiazepine 1,1-dioxide derivatives has been developed by the reaction of 2-azido-N-substituted benzenesulfonamides and propargyl bromide in basic alumina under microwave condition via [3+2] azide-alkyne cycloaddition reaction. This protocol has synthetic advantages in terms of low environmental impact and short reaction time.

Synthesis of 3-amino-1,2,4-benzothiadiazine 1,1-dioxides via a tandem aza-Wittig/heterocumulene annulation

Reaction of o-azidobenzenesulfonamides with polymer-supported triphenylphosphine affords the corresponding iminophosphoranes. Subsequent reaction with isocyanates gives 3-amino-1,2,4-benzothiadiazine 1,1-dioxides in high yields and purities. The reaction