1248344-23-1Relevant articles and documents
Development of Potent PfCLK3 Inhibitors Based on TCMDC-135051 as a New Class of Antimalarials
Mahindra, Amit,Janha, Omar,Mapesa, Kopano,Sanchez-Azqueta, Ana,Alam, Mahmood M.,Amambua-Ngwa, Alfred,Nwakanma, Davis C.,Tobin, Andrew B.,Jamieson, Andrew G.
, p. 9300 - 9315 (2020)
The protein kinase PfCLK3 plays a critical role in the regulation of malarial parasite RNA splicing and is essential for the survival of blood stage Plasmodium falciparum. We recently validated PfCLK3 as a drug target in malaria that offers prophylactic,
Total synthesis of (±)-Vertine with Z-selective RCM as a key step
Chausset-Boissarie, Laetitia,Arvai, Roman,Cumming, Graham R.,Besnard, Celine,Kuendig, E. Peter
supporting information; experimental part, p. 6264 - 6266 (2010/10/19)
A concise total synthesis of the strained pentacyclic alkaloid (±)-Vertine has been achieved in eleven steps with the key steps being pelletierine condensation, Suzuki-Miyaura coupling, and ring-closing metathesis.