162269-90-1

Basic information

• Product Name: Benzaldehyde, 3-bromo-4-(methoxymethoxy)-
• CAS NO: 162269-90-1
• Molecular Formula: C9H9BrO3
• Molecular Weight: 245.073
• Mol File: 162269-90-1.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 3-bromo-4-(methoxymethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 3-bromo-4-(methoxymethoxy)-(162269-90-1)
• EPA Substance Registry System: Benzaldehyde, 3-bromo-4-(methoxymethoxy)-(162269-90-1)

Safety Data

• Hazardous Substances Data: 162269-90-1(Hazardous Substances Data)

Upstream product

• 542-88-1 bis(2-chloromethyl)ether 
• 2973-78-6 3-bromo-4-hydroxybenzylaldehyde 
• 123-11-5 4-methoxy-benzaldehyde 
• 107-30-2 chloromethyl methyl ether 
• 123-08-0 4-hydroxy-benzaldehyde 
• 13057-17-5 bromethyl methyl ether 

Downstream Products

• 1020399-89-6 C₁₉H₁₇Br₃O₅ 
• 1020400-13-8 C₂₅H₂₆Br₂O₆ 
• 1020400-11-6 C₂₈H₂₄Br₂O₆ 
• 1020400-09-2 C₂₈H₂₄Br₂O₆ 
• 1020399-87-4 C₁₇H₁₅BrO₃ 
• 1020399-79-4 C₂₁H₂₀Br₂O₅ 
• 1065546-02-2 bipinnatone A 
• 1065546-06-6 bipinnatone B 
• 1333078-53-7 C₃₀H₅₀O₃Si 
• 1333078-60-6 C₂₅H₄₂O₃Si 
• 1333078-54-8 C₂₄H₃₆O₃ 
• 1333078-61-7 C₁₉H₂₈O₃ 
• 1333078-58-2 C₂₃H₂₉BrO₉ 
• 1333078-59-3 C₂₁H₂₅BrO₈ 

Relevant articles and documents

A study of enantioselective syntheses by Sharpless asymmetric oxidation for aryl sulfoxides containing oxygen groups at the ortho position

Abstract: While ortho-alkoxy aryl sulfoxides including various substituents were synthesized by Sharpless asymmetric oxidation reaction, we optimized the reaction conditions and screened better combination of starting materials to obtain high enantioselectivity. The result suggested new information that electron-withdrawing substituents on the aromatic ring have a strong influence upon enantioselectivity of the products. Also, several chiral ligands for Sharpless asymmetric oxidation reaction were evaluated to improve the enantioselectivity. Graphic abstract: High enantioselectivity of ortho-alkoxy aryl chiral sulfoxides have been achieved by Sharpless oxidation reaction using Ti(O-i-Pr)4 and diethyl tartrate under anhydrous condition. In particular, the enantioselctivity of products was influenced by electron-withdrawing substituents on the aromatic ring, such as nitro, ester and aldehyde groups.[Figure not available: see fulltext.]

Structure-Activity-Relationship-Aided Design and Synthesis of xCT Antiporter Inhibitors

The xCT antiporter is a cell membrane protein involved in active counter-transportation of glutamate (outflux) with cystine (influx) over the human cell membrane. This feature makes the xCT antiporter a crucial element of the biosynthesis of the vital free radical scavenger glutathione. The prodrug sulfasalazine, a medication for the treatment of ulcerative colitis, was previously proven to inhibit the xCT antiporter. Starting from sulfasalazine, a molecular scaffold jumping followed by SAR-assisted design and synthesis provided a series of styryl hydroxy-benzoic acid analogues that were biologically tested in vitro for their ability to decrease intracellular glutathione levels using four different cancer cell lines: A172 (glioma), A375 (melanoma), U87 (glioma) and MCF7 (breast carcinoma). Depletion of glutathione levels varied among the compounds as well as among the cell lines. Flow cytometry using propidium iodide and the annexin V marker demonstrated minimal toxicity in normal human astrocytes for a promising candidate molecule (E)-5-(2-([1,1′-biphenyl]-4-yl)vinyl)-2-hydroxybenzoic acid.

STYRYLBENZOTHIAZOLE DERIVATIVES AND USES IN IMAGING

This disclosure relates to styrylbenzothiazole derivatives for use as in vivo imaging agents for the diagnosis of Parkinson's disease (PD) or other degenerative disorders or conditions of the central nervous system. Early diagnosis is particularly advantageous as neuroprotective treatment can be applied to healthy neural cells to delay or even prevent the onset of debilitating clinical symptoms.