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1248350-25-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1248350-25-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,8,3,5 and 0 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1248350-25:
145 % 10 = 5
So 1248350-25-5 is a valid CAS Registry Number.

1248350-25-5Relevant articles and documents

Enantioselective synthesis of α-methyl carboxylic acids from readily available starting materials via chemoenzymatic dynamic kinetic resolution

Thalen, Lisa K.,Sumic, Anna,Bogar, Krisztian,Norinder, Jakob,Persson, Andreas K. Ae.,Baeckvall, Jan-E.

, p. 6842 - 6847 (2010)

An enantioselective method for the synthesis of α-methyl carboxylic acids starting from trans-cinnamaldehyde, a readily available and inexpensive compound, has been developed. Allylic alcohol 1 was obtained via a standard Grignard addition to trans-cinnamaldehyde. Dynamic kinetic resolution was applied to allylic alcohol 1 utilizing a ruthenium catalyst and either an (R)-selective lipase or an (S)-selective protease to provide the corresponding allylic esters in high yield and high ee. A copper-catalyzed allylic substitution was then applied to provide the corresponding alkenes with inversion of stereochemistry. Subsequent C-C double bond cleavage afforded pharmaceutically important α-methyl substituted carboxylic acids in high ee and overall yields of up to 76%.

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