124852-33-1Relevant academic research and scientific papers
Reaction of 2-Isoxazolines with Organolithiums in the Presence of Boron Trifluoride
Uno, Hidemitsu,Terakawa, Tetsuya,Suzuki, Hitomi
, p. 2730 - 2737 (2007/10/02)
In the presence of boron trifluoride,3,4,5-tri-, 3,5,5-tri and 3,5-disubstituted 2-isoxazolines underwent nucleophilic addition of alkyl- and aryllithiums to give 3,3,4,5-, 3,3,5,5-, and 3,3,5-substituted isoxazolidines in moderate to good yields.On the other hand, in the case of 3,4,5,5-tetrasubstituted isoxazolines, the addition did not proceed at all but proton abstraction took place to afford a "ate" complex of isoxazoline anions, formation of which was confirmed by deuteration and the aldol reaction with benzaldehyde.
Boron Trifluoride-Assisted Alkylation of 2-Isoxazolines. A novel Route to N-Unsubstituted Isoxazolines
Uno, Hidemitsu,Terakawa, Tetsuya,Suzuki, Hitomi
, p. 1079 - 1082 (2007/10/02)
In the presence of boron trifluoride, 2-isoxazolines undergo the addition of organolithiums to afford N-unsubstituted isoxazolines in moderate to good yields.
