124852-65-9

Upstream product

• 495-69-2 Hippuric Acid 
• 80459-48-9 4-tosyloxybenzaldehyde 

Downstream Products

• 136678-83-6 Toluene-4-sulfonic acid 4-[1-[4-(4,6-dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-5-oxo-2-phenyl-1,5-dihydro-imidazol-(4Z)-ylidenemethyl]-phenyl ester 
• 136678-82-5 Toluene-4-sulfonic acid 4-[5-oxo-2-phenyl-1-[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-1,5-dihydro-imidazol-(4Z)-ylidenemethyl]-phenyl ester 
• 124852-71-7 Toluene-4-sulfonic acid 4-[(Z)-2-benzoylamino-2-(3H-imidazo[4,5-b]pyridin-2-yl)-vinyl]-phenyl ester 
• 124852-74-0 Toluene-4-sulfonic acid 4-[1-(3-amino-pyridin-2-yl)-5-oxo-2-phenyl-1,5-dihydro-imidazol-(4Z)-ylidenemethyl]-phenyl ester 
• 124852-77-3 Toluene-4-sulfonic acid 4-[8-phenyl-imidazo[5',1':2,3]imidazo[4,5-b]pyridin-(6Z)-ylidenemethyl]-phenyl ester 
• 124852-68-2 Toluene-4-sulfonic acid 4-[(Z)-2-(3-amino-pyridin-2-ylcarbamoyl)-2-benzoylamino-vinyl]-phenyl ester 

Relevant academic research and scientific papers

SULFONATE ESTER-CONTAINING (IMIDAZOL-1-yl)-N-SUBSTITUTED BENZENESULFONAMIDES OF ANTICIPATED ANTINEOPLASTIC ACTIVITY

The stereospecific synthesis for a series of (Z)-4--4,5-dihydro-5-oxo-1H-imidazol-1-yl>-N-substituted benzenesulfonamide derivatives (VIa-o) was investigated with a view to prepare new pharmacologically active products of extended and/or improved antineoplastic activity.Owing to the weak nucleophilicity of the nitrogen nucleophiles under investigation, acetic acid mediatd cyclizations were followed for preparation of the required products.Additionally, the antimicrobial activity was screened for the compounds reported.Key words: Sulfonamide derivatives; stereospecific synthesis; antimicrobial activity

FACILE SYNTHESIS AND BIOLOGICAL ACTIVITY OF SULFONATE ESTER-CONTAINING IMIDAZOLYLPYRIDINE, IMIDAZO(4,5-b)PYRIDINE AND IMIDAZO(5',1':2,3)IMIDAZO(4,5-b)PYRIDINE DERIVATIVES

Different ring systems containing imidazole and/or pyridine moieties and accomodating sulfonate ester moiety in their structure were prepared via ring opening of 2-oxazolin-5-one derivatives under various reaction conditions.The assigned structures for the prepared compounds were established through elemental analysis, spectral data and if possible by alternative synthetic routes.The antimicrobial activity of the synthesized compounds was also investigated.