124870-33-3Relevant academic research and scientific papers
CLAY MONTMORILLONITE-CATALYZED REGIOSELECTIVE ADDITION OF SILYL KETENE ACETALS TO PYRIDINE DERIVATIVES: SYNTHESIS OF N-SILYLDIHYDROPYRIDINES
Onaka, Makoto,Ohno, Ryosuke,Izumi, Yusuke
, p. 747 - 750 (1989)
Clay montmorillnite is an effecient catalyst for addition of silyl ketene acetals to pyridine derivatives with electron-withdrawing groups to afford N-silyldihydropyridines.
Azine Activation via Silylium Catalysis
Obradors, Carla,List, Benjamin
supporting information, p. 6817 - 6822 (2021/05/29)
Practical, efficient, and general methods for the diversification of N-heterocycles have been a recurrent goal in chemical synthesis due to the ubiquitous influence of these motifs within bioactive frameworks. Here, we describe a direct, catalytic, and selective functionalization of azines via silylium activation. Our catalyst design enables mild conditions and a remarkable functional group tolerance in a one-pot setup.
METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS
-
Paragraph 1351-1352, (2021/11/06)
The subject matter described herein is directed to ferroportin inhibitor compounds of Formula (I) and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis, and also kidney injuries.
17a-HYDROXYLASE/C17,20-LYASE INHIBITORS
-
Paragraph 0970, (2014/03/21)
The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.
17α-HYDROXYLASE/C17,20-LYASE INHIBITORS
-
Page/Page column 156-157, (2012/04/04)
The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.
NOVEL PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
-
Page/Page column 28, (2008/06/13)
This invention relates to novel pyridine derivatives having an inhibitory effect on production of cytokines, which are involved in inflammatory responses, thus suggesting its usefulness as therapeutic agents for treating diseases related to inflammation, immune, chronic inflammation as well as an agent having an anti-inflammatory and analgesic effect. Further, this invention relates to a method of manufacturing the same and a pharmaceutical composition containing the same.
