36850-80-3

Basic information

• Product Name: Silane, [(1-methoxyethenyl)oxy]trimethyl-
• CAS NO: 36850-80-3
• Molecular Formula: C6H14O2Si
• Molecular Weight: 146.261
• Mol File: 36850-80-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Silane, [(1-methoxyethenyl)oxy]trimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, [(1-methoxyethenyl)oxy]trimethyl-(36850-80-3)
• EPA Substance Registry System: Silane, [(1-methoxyethenyl)oxy]trimethyl-(36850-80-3)

Safety Data

• Hazardous Substances Data: 36850-80-3(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 79-20-9 acetic acid methyl ester 

Downstream Products

• 56446-60-7 methyl (2-methyl-1,3-dioxolan-2-yl)acetate 
• 112052-21-8 methyl 2-(cyclohex-2-en-1-yl)acetate 
• 133967-46-1 methyl bicyclo<3.1.0>hex-6-syn-ylacetate 
• 54445-54-4 (+/-)-methyl 2-methylene-1-cyclohexaneacetate 
• 54445-57-7 methyl 3-(1-cyclohexenyl) propanoate 
• 128625-50-3 methyl (3R,4S)-5-cyclohexyl-3-hydroxy-4-(isopropoxycarbonyl)aminopentanoate 
• 128625-48-9 methyl (3S,4S)-5-cyclohexyl-3-hydroxy-4-(isopropoxycarbonyl)aminopentanoate 
• 127376-12-9 {2-[2-(4-Methoxy-2-oxo-cyclohex-3-enyl)-ethyl]-[1,3]dioxolan-2-yl}-acetic acid methyl ester 
• 60729-66-0 methyl cis-(5-carbomethoxy-1-cyclohexen-3-yl)acetate 
• 133967-41-6 methyl syn-3-carbomethoxybicyclo<3.1.0>hexane-6-acetate 
• 60729-66-0 methyl trans-(5-carbomethoxy-1-cyclohexen-3-yl)acetate 
• 142560-72-3 trans-3-benzyloxycarbonylamino-4-methoxycarbonylmethyl-2-azetidinone 
• 186886-72-6 (3S,5S,8S,9S)-9-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-8,10-dimethyl-3-trimethylsilanyloxy-undecanoic acid methyl ester 
• 17277-58-6 methyl (phenylsulfanyl)acetate 

Relevant articles and documents

The Structure and Function of Oestrogens. IX Synthesis of the trans Isomer of 5,5,10b-Trimethyl-4b,5,6,10b,11,12-hexahydrochrysene-2,8-diol

Alkylation of ketene methyl trimethylsilyl acetal (10) with 1ξ-acetoxy-6-methoxy-2-(p-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydronaphthalene (9) in the presence of zinc iodide gave 84percent of methyl (1'RS,2'RS)-2-ethanoate (11a).Cyclization of the derived acid (11b) with methanesulfonic acid gave 89percent of 2,8-dimethoxy-10b-methyl-cis-4b,10b,11,12-tetrahydrochrysen-6(5H)-one (12a), Clemmensen reduction of which afforded 52percent of 2,8-dimethoxy-4b-methyl-cis-4b,5,6,10b,11,12-hexahydrochrysene (12b).Oxidation of (12b) with dichlorodicyanobenzoquinone gave 70percent of the conjugated enone (4), which upon hydrogenation over 10percent palladium/charcoal gave a 5:1 ratio of 2,8-dimethoxy-10b-methyl-trans-4b,10b,11,12-tetrahydrochrysen-6(5H)-one (14) and the cis isomer (12a).Exhaustive methylation of the trans ketone (14) yielded 49percent of 2,8-dimethoxy-5,5,10b-trimethyl-trans-4b,10b,11,12-tetrahydrochrysen-6(5H)-one (16), which upon Clemmensen reduction followed by O-demethylation afforded 5,5,10b-trimethyl-trans-4b,5,6,10b,11,12-hexahydrochrysene-2,8-diol (2).