1248707-72-3Relevant academic research and scientific papers
IRREVERSIBLE INHIBITORS USEFUL FOR THE TREATMENT OF KINASE-RELATED PATHOLOGIES
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, (2011/04/24)
The present invention provides new compounds (I) having a kinase inhibitory activity and useful for treating cancer.
In vivo efficacy of natural product-inspired irreversible kinase inhibitors
Barluenga, Sofia,Jogireddy, Rajamalleswaramma,Koripelly, Girish K.,Winssinger, Nicolas
, p. 1692 - 1699 (2011/04/17)
Hypothemycin and related resorcylic acid lactones (RAL) bearing a cis-enone moiety have emerged as an alternative pharmacophore to heterocyclic motifs for kinase inhibition, and are endowed with a unique selectivity filter based on the irreversible reacti
