1248798-80-2

Upstream product

• 1248798-79-9 (S)-4-(allyloxy)-2-(3-azido-2,2-dimethylpropanoyloxy)-4-oxobutanoic acid 
• 436143-87-2 (R)-3-(3-Chloro-4-methoxy-phenyl)-2-[(E)-(5S,6S)-6-((4R,5R)-2,2-dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-5-hydroxy-hept-2-enoylamino]-propionic acid 2,2,2-trichloro-ethyl ester 

Downstream Products

• 1248798-82-4 C₄₀H₄₉ClN₂O₁₁ 

Relevant academic research and scientific papers

Approaches for the synthesis of functionalized cryptophycins

The first syntheses of bioactive cryptophycins functionalized at unit D were accomplished in a one-pot Staudinger reduction/cyclization step. An azido precursor for the lower part of the backbone was introduced to minimize protective group chemistry and enable a very convenient synthesis of cryptophycin-52 and unit D cryptophycin analogues containing an ester or a free carboxylic acid for bioconjugations. Both new cryptophycin derivatives show high biological activity in cytotoxicity assays.