436143-87-2

Upstream product

• 932739-33-8 (2S,3S)-2-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]hex-5-en-3-ol 
• 1248798-73-3 (R)-2-acryloylamino-3-(3-chloro-4-methoxyphenyl)propionic acid 2,2,2-trichloroethyl ester 
• 436143-85-0 (E)-(5S,6S)-6-((4R,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-5-hydroxy-hept-2-enoic acid allyl ester 
• 436143-84-9 3-(2,2-dimethyl-5-phenyl-[1.3]dioxolan-4-yl)-1-[1,3]dithian-2-yl-butan-2-ol 
• 436143-90-7 5-[1,3]dithian-2-yl-3-methyl-1-phenylpentane-1,2,4-triol 
• 436143-91-8 (3S,4S)-4-((4R,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-3-hydroxy-pentanal 
• 436143-83-8 2-methyl-7-phenyl-6,8-dioxabicyclo[3.2.1]octan-3-ol 
• 436143-89-4 (5S,6S,E)-6-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]-5-hydroxyhept-2-enoic acid 

Downstream Products

• 1248798-80-2 C₄₂H₅₀Cl₄N₄O₁₂ 
• 1248798-95-9 C₄₁H₅₂Cl₄N₄O₁₀ 
• 1424402-48-1 C₅₈H₆₇Cl₄N₅O₁₂ 
• 1424402-44-7 C₅₆H₆₃Cl₄N₅O₁₂ 
• 1424402-70-9 C₄₂H₅₄ClN₅O₉ 
• 1424402-69-6 C₄₂H₅₄ClN₅O₉ 
• 1424402-45-8 C₅₆H₆₃Cl₄N₅O₁₂ 
• 1424402-68-5 C₃₈H₄₈ClN₅O₈ 
• 1424402-65-2 C₃₆H₄₄ClN₅O₈ 
• 1424402-64-1 C₃₆H₄₄ClN₅O₈ 
• 1424402-58-3 C₄₁H₅₄ClN₅O₉ 
• 1424402-55-0 C₃₉H₅₀ClN₅O₉ 
• 1424402-54-9 C₃₉H₅₀ClN₅O₉ 
• 1424402-67-4 C₃₇H₄₆ClN₅O₈ 

Relevant academic research and scientific papers

Approaches for the synthesis of functionalized cryptophycins

The first syntheses of bioactive cryptophycins functionalized at unit D were accomplished in a one-pot Staudinger reduction/cyclization step. An azido precursor for the lower part of the backbone was introduced to minimize protective group chemistry and enable a very convenient synthesis of cryptophycin-52 and unit D cryptophycin analogues containing an ester or a free carboxylic acid for bioconjugations. Both new cryptophycin derivatives show high biological activity in cytotoxicity assays.

Stereospecific synthesis of cryptophycin 1

Matrix presented A brief stereospecific synthesis of cryptophycin 1 is described in which (R)-mandelic acid serves as the sole source of asymmetry for unit A. The key step is a hetero-Diels-Alder cycloaddition.