124909-82-6

Upstream product

• 500-99-2 3,5-dimethoxyphenol 
• 17874-42-9 2'-hydroxy-2,4',6'-trimethoxyacetophenone 
• 14639-73-7 1-(3,6-dihydroxy-2,4-dimethoxy-phenyl)-2-methoxy-ethanone 
• 59171-19-6 3-benzyloxy-4-methoxy-benzoic acid-anhydride 

Downstream Products

• 548-74-3 5,6,3′-trihydroxy-3,7,4′-trimethoxyflavonol 
• 154662-04-1 6-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,5,7-trimethoxychromen-4-one 
• 14397-72-9 5,6-diacetoxy-2-(3-acetoxy-4-methoxy-phenyl)-3,7-dimethoxy-chromen-4-one 
• 64190-88-1 3,4',5,6,7-pentahydroxy-3-methoxy-flavone 

Relevant academic research and scientific papers

Structure-activity requirements for flavone cytotoxicity and binding to tubulin

A series of 79 flavones related to centaureidin (3,6,4'-trimethoxy- 5,7,3'-trihydroxyflavone, 1) was screened for cytotoxicity in the NCI in vitro 60-cell line human tumor screen. The resulting cytotoxicity profiles of these flavones were compared for deg

STUDIES OF THE SELECTIVE O-ALKYLATION AND DEALKYLATION OF FLAVONOIDS. XII. A NEW, CONVENIENT METHOD FOR SYNTHESIZING 3,5-DIHYDROXY-6,7-DIMETHOXYFLAVONES FROM 3,5,6,7-TETRAMETHOXYFLAVONES

The 5-methoxy group on 3,5,6,7-tetramethoxyflavones and the 3-methoxy group on 3,6,7-trimethoxy-5-tosyloxy-flavones were selectively cleaved with anhydrous aluminum bromide in acetonitrile under controlled conditions without the cleavage of benzyloxy groups on the B ring.By the application of these reactions, seven 3,5-dihydroxy-6,7-dimethoxyflavones were easily synthesized from the corresponding 3,5,6,7-tetramethoxyflavones which were synthesized from 3,6-dihydroxy-2,4ω-trimethoxycetophenone by means of the Allan-Robinson reaction followed by methylation.Keywords: Allan-Robinson reaction ; selective demethylation; 3,5,6,7-tetramethoxyflavone; 5-hydroxy-3,6,7-trimethoxyflavone; 6-hydroxy-3,5,7-trimethoxyflavone; 5-tosyloxyflavone; 5,6-dihydroxy-3,7-dimethoxyflavone; 3,5-dihydroxy-6,7-dimethoxyflavone, 3,5-diacetoxy-6,7-dimethoxyflavone