124931-07-3Relevant academic research and scientific papers
Copper-catalyzed thioarylation or thioalkylation of halogenated 2-azetidinones using a thiol precursor
Ghotbabadi, Maryam Ravandeh,Zarei, Maaroof
, p. 1401 - 1408 (2018)
Abstract: The paper describes the synthesis and characterization data of new 2-azetidinones containing sulfide groups. Halogenated 2-azetidinones were synthesized by the reaction of ketenes, generated in situ from various carboxylic acid in the presence o
Pyrolysis of azetidinone derivatives: A versatile route towards electron-rich alkenes, C-1 allylation and/or homologation of aldehydes
Al-Hamdan, Nouf S.,Habib, Osama M.,Ibrahim, Yehia A.,Al-Awadi, Nouria A.,El-Dusouqui, Osman M. E.
, p. 21023 - 21031 (2014/06/09)
Pyrolysis of β-lactams and β-thiolactams led essentially to stereoselective synthesis of the high energy electron-rich Z-alkenes. Extension of this methodology to the pyrolysis of 3-allyloxy derivatives gave a simple direct route to the synthetically important 4-pentenal. These pyrolytic transformations convert aldehydes to aryloxyalkenes (a protected homologation) and 4-pentenal (a C-1 allylation and homologation). The starting 3-aryloxy and 3-allyloxy-β-lactams were synthesized by the standard Staudinger ketene-imine [2 + 2] cycloaddition. The corresponding β-thiolactams have readily been obtained in good yields by thiation of β-lactams with Lawesson's reagent. This journal is the Partner Organisations 2014.
