124940-29-0

Upstream product

• 51275-91-3 1-azido-3-chloro-propan-2-ol 
• 536-74-3 phenylacetylene 
• 106-89-8 epichlorohydrin 

Downstream Products

• 124940-27-8 1-(oxiran-2-yl-methyl)-4-phenyl-1H-[1,2,3]-triazole 

Relevant academic research and scientific papers

Three component, regioselective, one-pot synthesis of β-hydroxytriazoles from epoxides via 'click reactions'

2-Azidoalcohols derived in situ from epoxides and sodium azide undergo smooth coupling with alkynes under neutral conditions by means of 'click reactions' to furnish β-hydroxytriazoles in excellent yields and with high regioselectivity. This reaction proc

Epichlorohydrin as a Precursor of Functionally Substituted 1,2,3-Triazoles and Tetrazoles

Different procedures for azidation of epichlorohydrin and 2-(oxiran-2-ylmethyl)-5-phenyltetrazole in aqueous medium are considered. The synthetic potential of 1-azido-3-chloropropan-2-ol is demonstrated by its reactions with NH-unsubstituted azoles and 1.

CoFe2O4/Cu(OH)2 magnetic nanocomposite: An efficient and reusable heterogeneous catalyst for one-pot synthesis of β-hydroxy-1,4-disubstituted-1,2,3-triazoles from epoxides

A magnetically separable CoFe2O4/Cu(OH)2 nanocomposite was prepared and characterized by various techniques such as FESEM, EDS, TEM, XRD, VSM and FT-IR. This novel composite was used as a heterogeneous catalyst for the reg

A Peerless Aproach: Organophotoredox/Cu(I) Catalyzed, Regioselective, Visible Light Facilitated, Click Synthesis of 1,2,3-Triazoles via Azide–Alkyne [3 + 2] Cycloaddition

Abstract: A visible light initiated, mild, one pot, multicomponent copper catalyzed azide alkyne [3 + 2] cycloaddition in the presence of organo photoredox catalyst Eosin Y using EtOH:H2O as reaction medium for the synthesis of substituted 1,2,3-triazoles is reported. A facile regioselective ring opening of epoxides followed by 1, 3 dipolar cycloaddition with alkynes under CFL (Compact fluorescent light) irradiation as a source of visible light resulting in the formation of C–N bonds, is the characteristic feature of the present strategy. Scope of the present protocol is further extended by using benzyl chloride in place of epoxide. Graphical Abstract: [Figure not available: see fulltext.].

Synthesis of N-(oxyran-2-ylmethyl)triazoles and -tetrazoles

The alkylation of 5-phenyl-1H-tetrazole and 4-nitro-2H-1,2,3-triazole with 1-chloro-2,3-epoxypropane and cycloaddition of 1-azido-3-chloropropan-2-ol to acetylenic dipolarophiles gave the corresponding N-(3-chloro-2-hydroxypropyl)azoles as intermediate pr

A concise and simple click reaction catalyzed by immobilized Cu(I) in an ionic liquid leading to the synthesis of β-hydroxy triazoles

This study describes an ecocompatible, concise, and practically reliable approach for the regioselective synthesis of β-hydroxy triazoles via Huisgen's click coupling reaction among varied epoxides, NaN3, and suitable acetylenes catalysed by im

Click chemistry inspired synthesis of morpholine-fused triazoles

The synthesis of triazolyl azido alcohols from terminal alkyne via oxirane ring-opening of epichlorohydrin, followed by click reaction with alkynes, and subsequent azidation of chlorohydroxy triazoles was achieved under a one-pot methodology. The develope

SYNTHESIS OF C- AND N-SUBSTITUTED OXIRANYL-1,2,3-TRIAZOLES

N-Substituted oxiranyl-1,2,3-triazoles are formed during the cycloaddition of glycidyl azide to various acetylene compounds or during the treatment of triazolylchloropropanols with alkali.The condensation of formyl-1,2,3-triazoles with chloroacetic ester