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Chemical Properties

Colourless Oil

InChI:InChI=1/C3H6ClN3O/c4-1-3(8)2-6-7-5/h3,8H,1-2H2

Upstream product

• 96-23-1 1,3-Dichloro-2-propanol 
• 106-89-8 epichlorohydrin 
• 108071-62-1 1-azido-2-trimethylsilyloxy-3-chloro propane 

Downstream Products

• 80044-09-3 1-azido-2,3-epoxypropane 
• 124940-29-0 3-chloro-1-(4-phenyl-1H-1,2,3-triazol-1-yl)propan-1-ol 
• 124940-38-1 1-Chloro-3-(5-phenyl-[1,2,3]triazol-1-yl)-propan-2-ol 
• 3920-12-5 2-hydroxy-3-chloropropylamine 
• 923276-78-2 5-(azidomethyl)oxazolidin-2-one 

Relevant academic research and scientific papers

Multivalent manganese complex decorated amphiphilic dextran micelles as sensitive MRI probes

T1 contrast agents based on Mn(ii) were conjugated on amphiphilic dextran micelles via click chemistry. The obtained paramagnetic nanomicelle contrast agent has a higher T1 relaxivity (13.3 Mn mmol-1 s-1) and better sensitivity than those of free Mn(ii) complexes. Studies carried out in vivo suggest that this contrast agent has a better and long-acting vascular enhancement effect at a lower manganese dosage (0.1 Mn mmol kg-1 BW). This journal is

A gadolinium-complex-based theranostic prodrug for: In vivo tumour-targeted magnetic resonance imaging and therapy

Here we report a target-specific theranostic prodrug (1a) containing Gd-DOTA, biotin, and camptothecin (CPT) along with a disulfide self-immolative linker. This prodrug exhibits selective targeting towards tumour cells and tissues, stimuli-responsive controlled release, enhanced anticancer efficacy, and accurate diagnosis and real-time monitoring via contrast-enhanced magnetic resonance imaging (MRI).

Dual-drug loaded Janus graphene oxide-based thermoresponsive nanoparticles for targeted therapy

Graphene oxide (GO) is extensively recognized as an effective material in a variety of fields and specifically for various biomedical applications. However, the modification of each side of a GO sheet, needed for preparation of heterogeneous nanoparticles, is yet hypothetical and unclear. Here, we have developed a new strategy for the synthesis of two-faced GOs by simultaneous anchoring of different polymers with different hydro-affinity via Pickering emulsion (two-phase media). Alkynyl-modified GO was prepared for unsymmetrically attaching azidated-poly(?-caprolactone) (PCL) and (N-isopropylacrylamide-co-acrylamide-co-allylamine) terpolymer to the surface of GO through click reaction. During this reaction, a thermoresponsive nanoparticles with specific morphology, known as “Janus” nanostructure, will be produced. PCL/terpolymer homostructure was also fabricated via solution (one-phase) reaction, where two types of polymers were grafted on the both surfaces of GO disorderly, named “mixed” nanoparticles. In the following, drug loaded nanocarriers were synthesized by simultaneously using quercetin and 5-FU as hydrophobic and hydrophilic drugs. The bioapplicability of these nanoparticles were evaluated by comparison of their in vitro release profiles and cell cytotoxicity at two temperatures of 37 and 40 °C.

A multimeric MR-optical contrast agent for multimodal imaging

We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(iii) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic.

A GAP Replacement: Improved Synthesis of 3-Azidooxetane and Its Homopolymer Based on Sulfonic Acid Esters of Oxetan-3-ol

In the field of energetic binders, only hydroxy-terminated glycidyl azide polymer (GAP) has found widespread application and prevailed in the market. However, oxiranes such as glycidyl azide (GA) allow two ring-opening modes during polymerization and thus

Solvent-free Synthesis and Properties of Functionalized Hydrazines and Bishydrazines as Energetic Ingredients for Propulsion Applications

Functionalized hydrazines and bishydrazines are interesting straightforward precursors for accessing higher nitrogenated compounds. They offer structural diversity and promising energetic properties as well, namely for propulsion applications. A novel and

Epichlorohydrin as a Precursor of Functionally Substituted 1,2,3-Triazoles and Tetrazoles

Different procedures for azidation of epichlorohydrin and 2-(oxiran-2-ylmethyl)-5-phenyltetrazole in aqueous medium are considered. The synthetic potential of 1-azido-3-chloropropan-2-ol is demonstrated by its reactions with NH-unsubstituted azoles and 1.

Montmorillonite K10 catalyzed highly regioselective azidolysis of epoxides: A short and efficient synthesis of phenylglycine

A series of β‐hydroxyazides were effectively synthesized from the regioselective ring opening of epoxides by sodium azide using montmorillonite K10 as a novel heterogeneous catalyst in aqueous acetonitrile in good to excellent yields. The utility of this method has been demonstrated by achieving a short synthesis of phenylglycine in 33.5% overall yield.

Acetic acid functionalized ionic liquid systems: An efficient and recyclable catalyst for the regioselective ring opening of epoxides with NaN3

In the present study, an environmentally benign, efficient, and solvent-free procedure was developed for the synthesis of 1,2-azidoalcohols by the regioselective ring opening of some epoxides with sodium azide (NaN3) in the presence of an aceti

POLYPEPTIDES, PEPTIDES, AND PROTEINS FUNCTIONALIZED BY ALKYLATION OF THIOETHER GROUPS VIA RING-OPENING REACTIONS

Some embodiments of the invention involve methods for introduction of various functional groups onto polypeptides, peptides and proteins by alkylation of thioether (a.k.a. sulfide) groups by ring opening reactions, creating new compositions of matter that may be useful for medical therapeutic or diagnostic applications. The thioether groups may either be present in the polypeptides, or may be added to polypeptides by chemical modification, such as by alkylation of thiol (sulfhydryl) groups.