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CAS

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124953-43-1

4-(3-Chloro-isoxazole-5-carbonyl)-piperazine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 124953-43-1 Structure

  • Basic information

    1. Product Name: 4-(3-Chloro-isoxazole-5-carbonyl)-piperazine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide
    2. Synonyms:
    3. CAS NO:124953-43-1
    4. Molecular Formula:
    5. Molecular Weight: 435.891
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 124953-43-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(3-Chloro-isoxazole-5-carbonyl)-piperazine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(3-Chloro-isoxazole-5-carbonyl)-piperazine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide(124953-43-1)
    11. EPA Substance Registry System: 4-(3-Chloro-isoxazole-5-carbonyl)-piperazine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide(124953-43-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 124953-43-1(Hazardous Substances Data)

124953-43-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 124953-43-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,9,5 and 3 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 124953-43:
(8*1)+(7*2)+(6*4)+(5*9)+(4*5)+(3*3)+(2*4)+(1*3)=131
131 % 10 = 1
So 124953-43-1 is a valid CAS Registry Number.

124953-43-1Downstream Products

124953-43-1Relevant articles and documents

New isoxazole derivatives provided with antihypertensive activity

Carenzi,Chiarino,Napoletano,Reggiani,Sala,Sala

, p. 642 - 646 (2007/10/02)

A series of diazacycloalkane-quinazoline derivatives of isoxazoles were synthesized and tested in order to identify new potent and selective α1-antagonists. A preliminary screening by using in vitro tests such as binding assay (3H-prazosin and 3H-rauwolscine displacement) and analysis of antagonistic activity in isolated rat aorta (norepinephrine-induced response) and in isolated rat vas deferens (clonidine-induced response) indicated that many of these compounds exhibited a good affinity and selectivity towards α1-adrenergic receptors associated with potent pharmacological activity. In particular, a 3-bromo-5-isoxazolecarbonyl derivative, selected for further in vivo investigation, was provided with as high antihypertensive action as prazosin in spontaneously hypertensive rats (SHR) coupled to a shallow dose-response curve by route. Moreover, a higher ratio between oral antihypertensive dosis in SHR and normotensive rats was found with respect to reference compound prazosin.

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