124974-83-0

Basic information

• Product Name: 2-Ethyl-4-phenyl-3-butynenitrile
• CAS NO: 124974-83-0
• Molecular Weight: 169.226
• Mol File: 124974-83-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Ethyl-4-phenyl-3-butynenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethyl-4-phenyl-3-butynenitrile(124974-83-0)
• EPA Substance Registry System: 2-Ethyl-4-phenyl-3-butynenitrile(124974-83-0)

Safety Data

• Hazardous Substances Data: 124974-83-0(Hazardous Substances Data)

Upstream product

• 27975-78-6 1-phenyl-1-pentyn-3-ol 
• 5804-85-3 diethylaluminium cyanide 
• 536-74-3 phenylacetylene 
• 7677-24-9 trimethylsilyl cyanide 

Relevant articles and documents

Asymmetric Propargylic Radical Cyanation Enabled by Dual Organophotoredox and Copper Catalysis

The first asymmetric propargylic radical cyanation was realized through a dual photoredox and copper catalysis. An organic photocatalyst serves to both generate propargyl radicals and oxidize Cu(I) species to Cu(II) species. A chiral Cu complex functions as an efficient organometallic catalyst to resemble the propargyl radical and cyanide in an enantio-controlled manner. Thus, a diverse range of optically active propargyl cyanides were produced with high reaction efficiency and enantioselectivities (28 examples, 57-97% yields and 83-98% ee). Moreover, mechanistic investigations including experiments and density functional theory calculations were performed to illustrate on the reaction pathway and stereochemical results.