1249756-52-2

Upstream product

• 107047-10-9 p-bromobenzylazide 
• 107-19-7 propargyl alcohol 
• 106-40-1 4-bromo-aniline 
• 2101-88-4 1-azido-4-bromobenzene 

Downstream Products

• 1325725-16-3 1-(4-bromophenyl)-4-(fluoromethyl)-1H-1,2,3-triazole 
• 1373934-11-2 1-{3-[(1-(4-bromophenyl)-1H-[1,2,3]triazol-4-yl)methoxy]-2-hydroxypropyl}-2-hydroxymethyl-piperidine-3,4,5-triol 
• 1373934-06-5 C₁₂H₁₂BrN₃O₂ 
• 916151-04-7 1-(4-bromophenyl)-1H-1,2,3-triazole-4-carbaldehyde 
• 20320-17-6 1-(4-bromophenyl)-1H-1,2,3-triazole 
• 944901-52-4 1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl carboxylic acid 

Relevant academic research and scientific papers

(DHQD)2PHAL ligand-accelerated Cu-catalyzed azide-alkyne cycloaddition reactions in water at room temperature

Herein, we have described, a 'Click Chemistry' protocol for the rapid synthesis of 1,2,3-triazoles in water. (DHQD)2PHAL has been found to be an excellent accelerating ligand for the copper(i)-catalyzed azide-alkyne cycloaddition reaction under

NHC-copper complexes immobilized on magnetic nanoparticles: Synthesis and catalytic activity in the CuAAC reactions

A series of N-heterocyclic carbene copper(I) and rare copper(II) complexes (NHCCuCl or NHCCuCl2) were covalently immobilized directly on the surface of magnetic nanoparticles (MNPs) for the first time. The physicochemical properties were investigated by a broad range of techniques, including SEM and TEM microscopy, and TG analysis. The supported complexes exhibited excellent activity in the Huisgen cycloaddition with in situ generated azides. Unexpectedly, a direct comparison of NHCCuCl and NHCCuCl2 complexes anchored to the magnetic nanoparticles confirmed the higher activity of the latter for the formation of 1,2,3-triazoles, also under ascorbate-free conditions.

Anti-Lung Cancer Activities of 1,2,3-Triazole Curcumin Derivatives via Regulation of the MAPK/NF-κB/STAT3 Signaling Pathways

In this study, a series of curcumin derivatives containing 1,2,3-triazole were designed and synthesized, and their inhibitory activities against the proliferation of lung cancer cells were studied. Compound 5 k (3,4-dichlorobenzyltriazole methyl curcumin)

Synthesis and Anticancer Activity of (E)-5-[(1-Aryl-1H-1,2,3-triazol-4-yl)methylene]thiazolidine-2,4-diones

Abstract: A novel series of 1,2,3-triazolylthiazolidinedione analogs have been synthesized by the condensation of the corresponding 1-aryl-1H-1,2,3-triazole-4-carbaldehydes with thiazolidine-2,4-dione in the presence of KOH. The title compounds were evaluated for their in vitro anticancer activity using MTT assay against four cancer cell lines: A549 (lung), HT-29 (colon), MCF-7 (breast), and A375 (melanoma). Most compounds displayed good anticancer activity, but hydroxy- and nitro-substituted derivatives showed higher activity than the others.

Alternative Route Triggering Multistep Spin Crossover with Hysteresis in an Iron(II) Family Mediated by Flexible Anion Ordering

Multistep spin crossover (SCO) compounds have attracted much attention, since they can be great candidates for high-density multinary memory devices. The introduction of substituents, such as methyl (Me), chloro (Cl), bromo (Br), and methoxy (MeO) groups,

Catalytic performance of Cu(II)-supported graphene quantum dots modified NiFe2O4 as a proficient nano-catalyst in the synthesis of 1,2,3-triazoles

Abstract: NiFe2O4 nanoparticles are modified by graphene quantum dots (GQDs) and utilized to stabilize the Cu(II) nanoparticles as a novel magnetically retrievable catalytic system (Cu(II)/GQDs/NiFe2O4) for gree

Cu nanoparticles immobilized on modified magnetic zeolite for the synthesis of 1,2,3-triazoles under ultrasonic conditions

Magnetically recoverable copper nanoparticle-loaded natural zeolite (CuNPs/MZN) as an efficient catalyst was synthesized. The Fe3O4 magnetic nanoparticles were immobilized into the pores of natural clinoptilolite zeolite, which were

Synthesis, characterization, and investigation of catalytic activity of copper(II) porphyrin graphene oxide for azide–alkyne cycloaddition

Abstract: A covalently cross-linked graphene oxide (GO) catalyst was prepared by a cross-linking process using nucleophilic reaction of copper(II)‐coordinated 5,10,15,20-tetrakis(aminophenyl)porphyrin (CuPPh) with carboxyl groups at the edges of GO (GO–CuPPh). The structure of the catalyst was characterized using different techniques such as Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive x-ray spectroscopy (EDS), thermogravimetric analysis (TGA), and inductively coupled plasma (ICP) spectroscopy. All analyses confirmed successful covalent immobilization of CuPPh on GO. The activity of the catalyst was then studied for synthesis of 1,4-disubstituted 1,2,3-triazoles derivatives by reaction of various aryl azides and different terminal alkynes in mild reaction condition with good to excellent yield. Graphical abstract: [Figure not available: see fulltext.].

Design and synthesis of novel dehydroepiandrosterone analogues as potent antiproliferative agents

The aim of the present study was to determine the cytotoxic effects of a series of novel dehydroepiandrosterone derivatives containing triazole at the C16 position on human cancer cells. The cancer cells used in the present study were A549, Hel

An efficient NaHSO3-promoted protocol for chemoselective synthesis of 2-substituted benzimidazoles in water

An efficient protocol for chemoselective synthesis of 2-substituted benzimidazoles from a variety of aliphatic/aromatic/ heteroaryl aldehydes and o-phenylenediamine derivatives promoted by NaHSO3 in water had been developed. The amount of NaHSO3 had a great effect on the reaction selectivity of 2-substituted benzimidazole and 1,2-disubstituted benzimidazole when the reaction was carried out in water. When the amount of the NaHSO3 was more than 11 equivalents, the 2-substituted benzimidazole could be highly selectively formed as the sole product. NaHSO3 was firstly reacted with aldehyde to form the aldehyde sodium bisulfite, which reacted with o-phenylenediamine to form the 2-substituted benzimidazole and inhibited the formation of 1,2-disubstituted benzimidazole. This protocol solved the poor selectivity problem appearing in traditional method when cyclocondensation between o-phenylenediamine and aldehydes. The method also had advantage of simple work up by filtrating the single 2-substituted benzimidazole precipitates from reaction mixture at the end of the reaction without further purification. In addition, the method was applicable to both electron-rich and electron-poor starting materials, which was successfully used for synthesizing nine novel 2-substituted benzimidazole derivatives containing a 1,2,3-triazole moiety. They were characterized by NMR, IR and HRMS spectrum. Moreover, this method had been applied to a large scale synthesis of 2-substituted benzimidazole derivatives.