124993-53-9

Upstream product

• 19179-36-3 3,5-dihydroxycyanobenzene 
• 77-78-1 dimethyl sulfate 
• 19179-31-8 3,5-dimethoxy-benzonitrile 

Downstream Products

• 701915-86-8 2-(3-CYANO-5-METHOXYPHENOXY)-N-(2-methylpent-3-yn-2-yl)-3-methoxypropionamide 
• 149555-67-9 3-hydroxy-5-methoxybenzylamine 

Relevant academic research and scientific papers

Process for demethylating aromatic methyl ethers using 3-mercaptopropionic acid

The present application discloses a process for demethylating aromatic methyl ethers by reaction with 3-mercaptopropionic acid or salts thereof. One preferred example is the demethylation of venlafaxine forming O-desmethylvenlafaxine.

PROCESS FOR DEMETHYLATING AROMATIC METHYL ETHERS USING 3 -MERCAPTOPROPIONIC ACID

The present application discloses a process for demethylating aromatic methyl ethers by reaction with 3 -mercaptopropionic acid or salts thereof. One preferred example is the demethylation of venlafaxine forming 0 - desmethylvenlafaxine.

Process for the synthesis of biologically active oxygenated compounds by dealkylation of the corresponding alkylethers

Alkoxy aromatic compounds are conveniently dealkylated to the corresponding phenolic compounds by treatment with aluminum chloride/N,N-dimethyl aniline complex. Aromatic poly O-demethylation is a unique feature of this invention. This process is applicable to the manufacture of polyphenols such as Resveratrol, Oxyresveratrol, Gnetol.

2-(Diethylamino)ethanethiol, a new reagent for the odorless deprotection of aromatic methyl ethers

A new reagent for the deprotection of aromatic methyl ethers, 2-(diethylamino)ethanethiol, is reported. This compound, commercially available as its HCl salt, affords the corresponding phenols in good to excellent yields on a wide variety of substrates. A clear advantage of this method over the use of more common thiols, such as ethanethiol, is the easy extraction of both the deprotecting reagent and the byproduct 2-(diethylamino)ethyl methyl sulfide into the aqueous phase by quenching with dilute acid, which allows an essentially odorless workup.

Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 1. The aromatic 'A-region'

A series of analogues of capsaicin, the pungent principle of chilli peppers, was synthesized and tested in assays for capsaicin-like agonism in vitro. The results of these assays were compared with activities in an acute nociceptive model and a correlation was observed which established that the results of these in vitro assays were predictive of analgesia. Using a modular approach the structure-activity profile of specific regions of capsaicin congeners was established using an in vitro assay measuring 45Ca2+ uptake into neonatal rat dorsal root ganglia neurones. Substituted benzylnonanamides 2a-z and N-octyl-substituted phenylacetamides 4a-v were made to test the requirements for activity in the aromatic 'A-region' of the molecule. Compounds with the natural substitution pattern (2b and 4c) and the corresponding catechols (2i and 4g) were the most potent, although the catechols were less potent in vivo. Other substitution patterns have reduced activity. These results have established stringent structural requirements for capsaicin-like activity in this part of the molecule.