125-72-4 Usage
Uses
Orally active synthetic morphine analog. Analgesic (narcotic).
Controlled substance.
Brand name
Levo-Dromoran (Valeant).
Clinical Use
Levorphanol is a potent μ agonist (approximately sixfold greater than morphine), and its uses, side
effects, and physical dependence liability are like those of oxymorphone or hydromorphone.
Levorphanol is available in oral, subcutaneous, and intravenous dosage forms. The oral dose of
levorphanol is approximately twice the parenteral dose. This drug is unique among the μ agonists
in that its analgesic duration of action is 4 to 6 hours, whereas its clearance half-life is 11.4 hours.
Thus, effective analgesic doses of this agent can lead to a buildup of the drug in the body and
result in excessive sedation.
Check Digit Verification of cas no
The CAS Registry Mumber 125-72-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 5 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 125-72:
(5*1)+(4*2)+(3*5)+(2*7)+(1*2)=44
44 % 10 = 4
So 125-72-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H23NO.C4H6O6/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17;5-1(3(7)8)2(6)4(9)10/h5-6,11,14,16,19H,2-4,7-10H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t14-,16+,17+;/m0./s1
125-72-4Relevant articles and documents
METHODS FOR PREPARING LEVORPHANOL AND RELATED COMPOUNDS, AND COMPOSITIONS THEREOF
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Paragraph 0177-0182, (2020/04/29)
A method for producing substantially pure levorphanol and related compounds, when compared to the conventional process, is provided. In particular, a method for producing substantially pure levorphanol tartrate dihydrate is described. Also described are compositions comprising levorphanol and related compounds, particularly compositions comprising levorphanol tartrate dihydrate, levomethorphan, and norlevorphanol in which the levomethorphan and norlevorphanol are present in the composition in reduced levels.