1250364-18-1

Basic information

• Product Name: (Z)-6-ethoxy-2-(pyridin-4-ylmethylene)benzofuran-3(2H)-one
• Synonyms: (Z)-6-ethoxy-2-(pyridin-4-ylmethylene)benzofuran-3(2H)-one
• CAS NO: 1250364-18-1
• Molecular Weight: 267.284
• Mol File: 1250364-18-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-6-ethoxy-2-(pyridin-4-ylmethylene)benzofuran-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-6-ethoxy-2-(pyridin-4-ylmethylene)benzofuran-3(2H)-one(1250364-18-1)
• EPA Substance Registry System: (Z)-6-ethoxy-2-(pyridin-4-ylmethylene)benzofuran-3(2H)-one(1250364-18-1)

Safety Data

• Hazardous Substances Data: 1250364-18-1(Hazardous Substances Data)

Upstream product

• 6272-26-0 6-hydroxybenzofuran-3-one 

Downstream Products

• 1499195-76-4 (Z)-4-((6-ethoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)-1-(2-oxo-2-phenylethyl)pyridinium chloride 
• 1499195-75-3 (Z)-4-((6-ethoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)-1-(2-(4-fluorophenyl)-2-oxoethyl)pyridinium bromide 
• 1499195-78-6 (Z)-1-(2-(4-bromophenyl)-2-oxoethyl)-4-((6-ethoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium bromide 
• 1499195-74-2 (Z)-4-((6-ethoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)-1-(2-oxo-2-p-tolylethyl)pyridinium chloride 
• 1499195-77-5 (Z)-1-(2-(3,4-dihydroxyphenyl)-2-oxoethyl)-4-((6-ethoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium chloride 
• 1250364-43-2 (Z)-1-(3-fluorobenzyl)-4-((6-ethoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium chloride 
• 1250364-45-4 (Z)-1-(4-fluorobenzyl)-4-((6-ethoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium bromide 
• 1250364-50-1 (Z)-1-(4-methylbenzyl)-4-((6-ethoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium chloride 
• 1250364-41-0 (Z)-1-(2-fluorobenzyl)-4-((6-ethoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium chloride 
• 1250364-47-6 (Z)-1-(2-methylbenzyl)-4-((6-ethoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium chloride 
• 1250364-40-9 (Z)-1-benzyl-4-((6-ethoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium bromide 
• 1250364-49-8 (Z)-1-(3-methylbenzyl)-4-((6-ethoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium chloride 

Relevant articles and documents

Synthesis of some new 3-coumaranone and coumarin derivatives as dual inhibitors of acetyl- and butyrylcholinesterase

A novel series of coumarin and 3-coumaranone derivatives encompassing the phenacyl pyridinium moiety were synthesized and evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activity using Ellman's method. All compounds presented inhibitory activity against both AChE and BuChE in the micromolar range. The molecular docking simulations revealed that all compounds were dual binding site inhibitors of AChE. A kinetic study was performed and the mechanism of enzyme inhibition was proved to be of mixed type. All compounds were tested for their antioxidant activity and no significant activity was observed.