1250436-23-7

Upstream product

• 98-88-4 benzoyl chloride 
• 108-98-5 thiophenol 
• 167612-34-2 phenyl 6-deoxy-2,3,4-tri-O-acetyl-1-thio-β-L-galactopyranoside 
• 187233-24-5 phenyl 6-deoxy-1-thio-β-L-galactopyranoside 
• 73-34-7 6-deoxy-L-galactose 
• 7404-35-5 1,2,3,4-tetra-O-acetyl-L-fucopyranose 
• 196397-59-8 phenyl 3,4-O-isopropylidene-1-thio-β-L-fucopyranoside 
• 848416-65-9 phenyl 2-O-benzyl-3,4-O-isopropylidene-1-thio-β-L-fucopyranoside 

Downstream Products

• 1454893-61-8 benzyl 3-O-(3,4-di-O-benzoyl-2-O-benzyl-α-L-fucopyranosyl)-3',4'-O-isopropylidene-2,6,2',6'-tetra-O-benzoyl-β-lactoside 
• 1393599-61-5 5-(methoxycarbonyl)pentyl 3,4-di-O-benzoyl-2-O-benzyl-α-L-fucopyranosyl-(1→2)-3,6-di-O-benzyl-4-O-methyl-β-D-galactopyranosyl-(1→3)-2-azido-4,6-O-benzylidene-2-deoxy-α-D-galactopyranoside 
• 1393599-71-7 5-(methoxycarbonyl)pentyl 3,4-di-O-benzoyl-2-O-benzyl-α-L-fucopyranosyl-(1→2)-3,4,6-tri-O-benzyl-β-D-galactopyranosyl-(1→3)-2-azido-4,6-O-benzylidene-2-deoxy-α-D-galactopyranoside 

Relevant academic research and scientific papers

NOVEL METHOD FOR THE SYNTHESIS OF A TRISACCHARIDE

The present invention relates to an improved synthesis of a trisaccharide of the formula, novel intermediates used in the synthesis and the preparation of the intermediates.

Synthesis, antigenicity against human sera and structure-activity relationships of carbohydrate moieties from toxocara larvae and their analogues

Stereocontrolled syntheses of biotin-labeled oligosaccharide portions containing the Galβ1-3GalNAc core of the TES-glycoprotein antigen obtained from larvae of the parasite Toxocara and their analogues have been accomplished. Trisaccharides Fuc2Meα1- 2Gal4Meβ1-3GalNAcα1-OR (A), Fucα1-2Gal4Meβ1-3GalNAcα1-OR (B), Fuc2Meα1- 2Galβ1-3GalNAcα1-OR (C), Fucα1-2Galβ1-3GalNAcα1-OR (D) and a disaccharide Fuc2Meα1-2Gal4Meβ1-OR (E) (R = biotinylated probe) were synthesized by block synthesis using 5-(methoxycarbonyl)pentyl-2,3, 4,6-tetra-O-acetyl-β-D-galactopyranosyl- (1→3)-2-azide-4-O-benzyl-2- deoxy-α-D-galactopyranoside as a common glycosyl acceptor. We examined the antigenicity of these five oligosaccharides by enzyme linked immunosorbent assay (ELISA). Our results demonstrate that the O-methyl groups in these oligosaccharides are important for their antigenicity and the biotinylated oligosaccharides A, B, C and E have high serodiagnostic potential to detect infections caused by Toxocara larvae.

SYNTHESIS OF 2 ' -O-FUCOSYLLACTOSE

The present invention relates to an improved synthesis of a trisaccharide of the formula, novel intermediates used in the synthesis and the preparation of the intermediates.